{"id":980,"date":"2026-05-19T09:51:55","date_gmt":"2026-05-19T02:51:55","guid":{"rendered":"https:\/\/opv.vn\/?post_type=product&p=980"},"modified":"2026-05-19T09:51:55","modified_gmt":"2026-05-19T02:51:55","slug":"ameprazol-20-40","status":"publish","type":"product","link":"https:\/\/opv.vn\/en\/ameprazol-20-40\/","title":{"rendered":"Ameprazol 20, 40"},"content":{"rendered":"

TH\u00c0NH PH\u1ea6N: <\/strong><\/p>\n

Vi\u00ean nang AMEPRAZOL\u00ae<\/sup> 20 :<\/strong> M\u1ed7i vi\u00ean nang ch\u1ee9a:<\/p>\n

Esomeprazole…………………………… 20 mg<\/p>\n

( d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t tan trong ru\u1ed9t ch\u1ee9a 8,5% (kl\/kl) Esomeprazole magnesi)<\/p>\n

Vi\u00ean nang AMEPRAZOL\u00ae<\/sup> 40 :<\/strong> M\u1ed7i vi\u00ean nang ch\u1ee9a:<\/p>\n

Esomeprazole…………………………… 40 mg<\/p>\n

( d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t tan trong ru\u1ed9t ch\u1ee9a 8,5% (kl\/kl) Esomeprazole magnesi )<\/p>\n

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D\u01af\u1ee2C L\u1ef0C H\u1eccC:<\/strong><\/p>\n

Esomeprazole l\u00e0 d\u1ea1ng \u0111\u1ed3ng ph\u00e2n S- c\u1ee7a omeprazole v\u00e0 l\u00e0m gi\u1ea3m s\u1ef1 b\u00e0i ti\u1ebft acid d\u1ea1 d\u00e0y b\u1eb1ng m\u1ed9t c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng chuy\u00ean bi\u1ec7t. Thu\u1ed1c l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf \u0111\u1eb7c hi\u1ec7u b\u01a1m acid \u1edf t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y. C\u1ea3 hai d\u1ea1ng \u0111\u1ed3ng ph\u00e2n R- v\u00e0 S- c\u1ee7a omeprazole \u0111\u1ec1u c\u00f3 t\u00e1c \u0111\u1ed9ng d\u01b0\u1ee3c l\u1ef1c h\u1ecdc t\u01b0\u01a1ng t\u1ef1.<\/p>\n

V\u1ecb tr\u00ed v\u00e0 c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng<\/em><\/p>\n

Esomeprazole l\u00e0 m\u1ed9t base y\u1ebfu, \u0111\u01b0\u1ee3c t\u1eadp trung v\u00e0 bi\u1ebfn \u0111\u1ed5i th\u00e0nh d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh trong m\u00f4i tr\u01b0\u1eddng acid cao \u1edf ti\u1ec3u qu\u1ea3n \u1ed1ng ch\u1ebf ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh, t\u1ea1i \u0111\u00e2y thu\u1ed1c s\u1ebd \u1ee9c ch\u1ebf men H+<\/sup>K+<\/sup>-ATPase (b\u01a1m acid) v\u00e0 \u1ee9c ch\u1ebf c\u1ea3 s\u1ef1 ti\u1ebft d\u1ecbch c\u01a1 b\u1ea3n l\u1eabn s\u1ef1 ti\u1ebft d\u1ecbch do k\u00edch th\u00edch.<\/p>\n

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D\u01af\u1ee2C \u0110\u1ed8NG H\u1eccC:<\/strong><\/p>\n

Esomeprazole \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c kho\u1ea3ng 1 \u0111\u1ebfn 2 gi\u1edd sau khi u\u1ed1ng. Thu\u1ed1c d\u1ec5 b\u1ecb h\u1ee7y \u1edf m\u00f4i tr\u01b0\u1eddng acid trong d\u1ea1 d\u00e0y v\u00e0 \u0111\u01b0\u1ee3c u\u1ed1ng d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t tan trong ru\u1ed9t. \u0110\u1ed9 sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i l\u00e0 64% sau khi u\u1ed1ng li\u1ec1u \u0111\u01a1n 40 mg v\u00e0 t\u0103ng l\u00ean 89 % sau khi d\u00f9ng li\u1ec1u l\u1eb7p l\u1ea1i 1 l\u1ea7n\/ng\u00e0y. \u0110\u1ed1i v\u1edbi li\u1ec1u esomeprazole 20 mg, c\u00e1c tr\u1ecb s\u1ed1 n\u00e0y t\u01b0\u01a1ng \u1ee9ng l\u00e0 50 % v\u00e0 68 %.<\/p>\n

Th\u1ee9c \u0103n l\u00e0m ch\u1eadm v\u00e0 gi\u1ea3m s\u1ef1 h\u1ea5p thu c\u1ee7a esomeprazole, nh\u01b0ng \u0111i\u1ec1u n\u00e0y kh\u00f4ng thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn t\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c l\u00ean s\u1ef1 ti\u1ebft acid d\u1ea1 d\u00e0y. Kho\u1ea3ng 97 % esomeprazole li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n

Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ed9ng r\u00e3i \u1edf gan nh\u1edd h\u1ec7 th\u1ed1ng men P450 isoenzyme CYP2C19, t\u1ea1o th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a hydroxyl v\u00e0 desmethyl, c\u00e1c ch\u1ea5t n\u00e0y kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ti\u1ebft acid d\u1ea1 d\u00e0y. Ph\u1ea7n c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a nh\u1edd men cytochrome P450 isoenzyme CYP3A4 t\u1ea1o th\u00e0nh esomeprazole sulfone. Khi d\u00f9ng li\u1ec1u l\u1eb7p l\u1ea1i, c\u00f3 s\u1ef1 gi\u1ea3m chuy\u1ec3n h\u00f3a \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u v\u00e0 gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i to\u00e0n than, c\u00f3 l\u1ebd do s\u1ef1 \u1ee9c ch\u1ebf men CYP2C19. Tuy nhi\u00ean, kh\u00f4ng c\u00f3 khuynh h\u01b0\u1edbng t\u00edch l\u0169y khi d\u00f9ng thu\u1ed1c m\u1ed9t l\u1ea7n\/ng\u00e0y. Th\u1eddi gian b\u00e1n h\u1ee7y trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 1,3 gi\u1edd. Kho\u1ea3ng 80 % li\u1ec1u u\u1ed1ng \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a, ph\u1ea7n c\u00f2n l\u1ea1i th\u1ea3i tr\u1eeb qua ph\u00e2n.<\/p>\n

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CH\u1ec8 \u0110\u1ecaNH:<\/strong><\/p>\n

AMEPRAZOL \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u1edf c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/p>\n

B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n (GERD)<\/em><\/p>\n

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  • \u0110i\u1ec1u tr\u1ecb vi\u00eam x\u01b0\u1edbc th\u1ef1c qu\u1ea3n do tr\u00e0o ng\u01b0\u1ee3c<\/li>\n
  • \u0110i\u1ec1u tr\u1ecb ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t vi\u00eam th\u1ef1c qu\u1ea3n \u0111\u00e3 ch\u1eefa l\u00e0nh<\/li>\n
  • \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n (GERD)<\/li>\n<\/ul>\n

    K\u1ebft h\u1ee3p v\u1edbi m\u1ed9t ph\u00e1c \u0111\u1ed3 kh\u00e1ng khu\u1ea9n th\u00edch h\u1ee3p \u0111\u1ec3 ti\u1ec7t tr\u1eeb vi khu\u1ea9n Helicobacter pylori v\u00e0 <\/em><\/p>\n

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    • Ch\u1eefa l\u00e0nh v\u1ebft lo\u00e9t t\u00e1 tr\u00e0ng c\u00f3 nhi\u1ec5m vi khu\u1ea9n Helicobacter pylori <\/em><\/li>\n
    • Ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng c\u00f3 nhi\u1ec5m vi khu\u1ea9n Helicobacter pylori<\/em><\/li>\n<\/ul>\n

      B\u1ec7nh nh\u00e2n c\u1ea7n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid li\u00ean t\u1ee5c<\/em><\/p>\n

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      • L\u00e0m l\u00e0nh v\u1ebft lo\u00e9t d\u1ea1 d\u00e0y do d\u00f9ng thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid<\/li>\n
      • Ph\u00f2ng ng\u1eeba lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng do d\u00f9ng thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1.<\/li>\n<\/ul>\n

        \u0110i\u1ec1u tr\u1ecb ti\u1ebfp n\u1ed1i sau khi ng\u0103n ng\u1eeba t\u00e1i xu\u1ea5t huy\u1ebft d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng b\u1eb1ng thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch.<\/em><\/p>\n

        \u0110i\u1ec1u tr\u1ecb h\u1ed9i ch\u1ee9ng Zollinger Ellison.<\/em><\/p>\n

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        C\u00c1CH D\u00d9NG-LI\u1ec0U D\u00d9NG:<\/strong><\/p>\n

        U\u1ed1ng nguy\u00ean vi\u00ean thu\u1ed1c v\u1edbi n\u01b0\u1edbc ho\u1eb7c th\u1ee9c u\u1ed1ng l\u1ecfng. Kh\u00f4ng \u0111\u01b0\u1ee3c nhai ho\u1eb7c nghi\u1ec1n n\u00e1t c\u00e1c vi h\u1ea1t.<\/p>\n

        Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean:<\/strong><\/p>\n

        B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n (GERD)<\/em><\/p>\n

        \u0110i\u1ec1u tr\u1ecb vi\u00eam x\u01b0\u1edbc th\u1ef1c qu\u1ea3n do tr\u00e0o ng\u01b0\u1ee3c:<\/u><\/p>\n

        40 mg x 1 l\u1ea7n\/ng\u00e0y trong 4 tu\u1ea7n. N\u00ean \u0111i\u1ec1u tr\u1ecb th\u00eam 4 tu\u1ea7n n\u1eefa cho b\u1ec7nh nh\u00e2n vi\u00eam th\u1ef1c qu\u1ea3n ch\u01b0a \u0111\u01b0\u1ee3c ch\u1eefa l\u00e0nh hay v\u1eabn c\u00f2n tri\u1ec7u ch\u1ee9ng.<\/p>\n

        \u0110i\u1ec1u tr\u1ecb ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t vi\u00eam th\u1ef1c qu\u1ea3n \u0111\u00e3 ch\u1eefa l\u00e0nh:<\/u><\/p>\n

        20 mg x 1 l\u1ea7n\/ng\u00e0y.<\/p>\n

        \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n (GERD):<\/u><\/p>\n

        20 mg x 1 l\u1ea7n\/ng\u00e0y \u1edf b\u1ec7nh nh\u00e2n kh\u00f4ng b\u1ecb vi\u00eam th\u1ef1c qu\u1ea3n. N\u1ebfu s\u1ef1 ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 4 tu\u1ea7n, b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c ki\u1ec3m tra k\u1ef9 h\u01a1n \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u1ea9n \u0111o\u00e1n. Khi \u0111\u00e3 h\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng, vi\u1ec7c ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng sau \u0111\u00f3 c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c li\u1ec1u 20 mg x 1 l\u1ea7n\/ng\u00e0y.<\/p>\n

        \u1ede ng\u01b0\u1eddi l\u1edbn, c\u00f3 th\u1ec3 d\u00f9ng ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb li\u1ec1u 20 mg x 1 l\u1ea7n\/ng\u00e0y, khi c\u1ea7n thi\u1ebft.<\/p>\n

        Ng\u01b0\u1eddi l\u1edbn:<\/strong><\/p>\n

        K\u1ebft h\u1ee3p v\u1edbi m\u1ed9t ph\u00e1c \u0111\u1ed3 kh\u00e1ng khu\u1ea9n th\u00edch h\u1ee3p \u0111\u1ec3 di\u1ec7t tr\u1eeb vi khu\u1ea9n Helicobacter pylori v\u00e0<\/em><\/p>\n

        Ch\u1eefa l\u00e0nh lo\u00e9t t\u00e1 tr\u00e0ng c\u00f3 nhi\u1ec5m vi khu\u1ea9n Helicobacter pylori v\u00e0 ph\u00f2ng ng\u1eeba t\u00e1i ph\u00e1t lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng \u1edf b\u1ec7nh nh\u00e2n lo\u00e9t c\u00f3 nhi\u1ec5m Helicobacter pylori:<\/u><\/p>\n

        Esomeprazole 20 mg, amoxicillin 1 g v\u00e0 clarithromycin 500 mg, t\u1ea5t c\u1ea3 \u0111\u01b0\u1ee3c d\u00f9ng 2 l\u1ea7n\/ng\u00e0y trong 7 ng\u00e0y.<\/p>\n

        B\u1ec7nh nh\u00e2n c\u1ea7n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng <\/em>thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid li\u00ean t\u1ee5c<\/em><\/p>\n

        Ch\u1eefa l\u00e0nh lo\u00e9t d\u1ea1 d\u00e0y do d\u00f9ng thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid:<\/u><\/p>\n

        Li\u1ec1u th\u00f4ng th\u01b0\u1eddng 20 mg, 1 l\u1ea7n\/ng\u00e0y. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb l\u00e0 4-8 tu\u1ea7n.<\/p>\n

        Ph\u00f2ng ng\u1eeba lo\u00e9t d\u1ea1 d\u00e0y v\u00e0 lo\u00e9t t\u00e1 tr\u00e0ng do d\u00f9ng thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1:<\/u><\/p>\n

        20 mg, 1 l\u1ea7n\/ng\u00e0y.<\/p>\n

        \u0110i\u1ec1u tr\u1ecb ti\u1ebfp n\u1ed1i sau khi ng\u0103n ng\u1eeba t\u00e1i xu\u1ea5t huy\u1ebft d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng b\u1eb1ng thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch.<\/em><\/p>\n

        40 mg, 1 l\u1ea7n\/ng\u00e0y trong 4 tu\u1ea7n sau khi ph\u00f2ng ng\u1eeba t\u00e1i xu\u1ea5t huy\u1ebft d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng b\u1eb1ng thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch.<\/p>\n

        \u0110i\u1ec1u tr\u1ecb h\u1ed9i ch\u1ee9ng Zollinger Ellison<\/em><\/p>\n

        Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o l\u00e0 esomeprazole 40 mg x 2 l\u1ea7n\/ng\u00e0y. Sau \u0111\u00f3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n. Ph\u1ea7n l\u1edbn b\u1ec7nh nh\u00e2n \u0111\u00e1p \u1ee9ng li\u1ec1u t\u1eeb 80 \u0111\u1ebfn 160 mg esomeprazole\/ng\u00e0y. Khi u\u1ed1ng li\u1ec1u h\u00e0ng ng\u00e0y l\u1edbn h\u01a1n 80 mg, n\u00ean chia li\u1ec1u d\u00f9ng th\u00e0nh 2 l\u1ea7n\/ng\u00e0y.<\/p>\n

        Tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i: <\/strong><\/p>\n

        Kh\u00f4ng n\u00ean d\u00f9ng esomeprazole cho tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i v\u00ec ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7.<\/p>\n

        Ng\u01b0\u1eddi t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng th\u1eadn:<\/strong><\/p>\n

        Kh\u00f4ng c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng th\u1eadn nh\u1eb9 v\u00e0 trung b\u00ecnh.<\/p>\n

        Ng\u01b0\u1eddi t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng gan:<\/strong><\/p>\n

        Kh\u00f4ng c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n t\u1ed5n th\u01b0\u01a1ng gan \u1edf m\u1ee9c \u0111\u1ed9 t\u1eeb nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh. \u1ede b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng, kh\u00f4ng n\u00ean d\u00f9ng qu\u00e1 20 mg\/ng\u00e0y.<\/p>\n

        Ng\u01b0\u1eddi cao tu\u1ed5i:<\/strong><\/p>\n

        Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n

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        CH\u1ed0NG CH\u1ec8 \u0110\u1ecaNH: <\/strong><\/p>\n

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        • Ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi esomeprazole, c\u00e1c thu\u1ed1c c\u00f3 nh\u00f3m benzimidazole v\u00e0 th\u00e0nh ph\u1ea7n kh\u00e1c trong c\u00f4ng th\u1ee9c.<\/li>\n
        • D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi atazanavir ho\u1eb7c nelfinavir.\u00a0<\/strong><\/li>\n<\/ul>\n
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          L\u01afU \u00dd V\u00c0 TH\u1eacN TR\u1eccNG:<\/strong><\/p>\n

            \n
          • Khi c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n b\u1ea5t k\u1ef3 m\u1ed9t tri\u1ec7u ch\u1ee9ng b\u00e1o \u0111\u1ed9ng n\u00e0o (nh\u01b0 l\u00e0 gi\u1ea3m c\u00e2n \u0111\u00e1ng k\u1ec3 kh\u00f4ng ch\u1ee7 \u00fd, n\u00f4n t\u00e1i ph\u00e1t, kh\u00f3 nu\u1ed1t, n\u00f4n ra m\u00e1u hay \u0111\u1ea1i ti\u1ec7n ph\u00e2n \u0111en) v\u00e0 khi b\u1ecb ho\u1eb7c nghi ng\u1edd lo\u00e9t d\u1ea1 d\u00e0y, n\u00ean lo\u1ea1i tr\u1eeb b\u1ec7nh l\u00fd \u00e1c t\u00ednh v\u00ec \u0111i\u1ec1u tr\u1ecb b\u1eb1ng esomeprazole c\u00f3 th\u1ec3 l\u00e0m che khu\u1ea5t c\u00e1c tri\u1ec7u ch\u1ee9ng ung th\u01b0 d\u1ea1 d\u00e0y v\u00e0 ch\u1eadm tr\u1ec5 vi\u1ec7c ch\u1ea9n \u0111o\u00e1n ung th\u01b0 d\u1ea1 d\u00e0y.<\/li>\n
          • Do \u00edt kinh nghi\u1ec7m v\u1ec1 vi\u1ec7c d\u00f9ng thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng, n\u00ean th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u tr\u1ecb \u1edf c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y.<\/li>\n
          • B\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb th\u1eddi gian d\u00e0i (\u0111\u1eb7c bi\u1ec7t nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb h\u01a1n 1 n\u0103m) n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean.<\/li>\n
          • B\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb c\u1ea7n li\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 n\u1ebfu c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng thay \u0111\u1ed5i. Khi k\u00ea toa thu\u1ed1c esomeprazole, c\u1ea7n xem x\u00e9t \u0111\u1ebfn s\u1ef1 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c do n\u1ed3ng \u0111\u1ed9 esomeprazole trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 thay \u0111\u1ed5i.<\/li>\n
          • Khi k\u00ea toa thu\u1ed1c esomeprazole \u0111\u1ec3 di\u1ec7t tr\u1eeb Helicobacter pylori,<\/em> n\u00ean xem x\u00e9t t\u01b0\u01a1ng t\u00e1c c\u1ee7a c\u00e1c thu\u1ed1c c\u00f3 trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb 3 thu\u1ed1c. Clarithromycin l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4, v\u00ec v\u1eady n\u00ean xem x\u00e9t ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u00e0 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u1edbi clarithromycin khi d\u00f9ng ph\u00e1c \u0111\u1ed3 3 thu\u1ed1c cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng c\u00e1c thu\u1ed1c kh\u00e1c chuy\u1ec3n h\u00f3a qua CYP3A4 nh\u01b0 cisapride.<\/li>\n
          • Ph\u1ee5 n\u1eef c\u00f3 thai: <\/strong>Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u1ec1 vi\u1ec7c d\u00f9ng esomeprazole tr\u00ean ph\u1ee5 n\u1eef c\u00f3 thai. Nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt, esomeprazole kh\u00f4ng g\u00e2y nguy h\u1ea1i tr\u1ef1c ti\u1ebfp hay gi\u00e1n ti\u1ebfp l\u00ean s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ph\u00f4i thai. N\u00ean th\u1eadn tr\u1ecdng khi k\u00ea toa cho ph\u1ee5 n\u1eef c\u00f3 thai.<\/li>\n
          • Ph\u1ee5 n\u1eef cho con b\u00fa: <\/strong>Ch\u01b0a bi\u1ebft esomeprazole c\u00f3 ti\u1ebft ra s\u1eefa m\u1eb9 hay kh\u00f4ng. Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o tr\u00ean ph\u1ee5 n\u1eef cho con b\u00fa \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. V\u00ec v\u1eady, kh\u00f4ng n\u00ean d\u00f9ng esomeprazole trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/li>\n<\/ul>\n
            \n

            T\u00c1C D\u1ee4NG KH\u00d4NG MONG MU\u1ed0N:<\/strong><\/p>\n

            Nh\u1ee9c \u0111\u1ea7u, \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, \u0111\u1ea7y b\u1ee5ng, bu\u1ed3n n\u00f4n ho\u1eb7c n\u00f4n.<\/p>\n

            \u00cdt g\u1eb7p:<\/em> Ph\u00f9 ngo\u1ea1i bi\u00ean, m\u1ea5t ng\u1ee7, ch\u00f3ng m\u1eb7t, d\u1ecb c\u1ea3m, ng\u1ee7 g\u00e0, ch\u00f3ng m\u1eb7t, kh\u00f4 mi\u1ec7ng, t\u0103ng men gan, vi\u00eam da, ng\u1ee9a, n\u1ed5i m\u1ea9n, m\u1ec1 \u0111ay.<\/p>\n

            Hi\u1ebfm g\u1eb7p:<\/em> Gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn (nh\u01b0 s\u1ed1t, ph\u00f9 m\u1ea1ch, ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7\/s\u1ed1c ph\u1ea3n v\u1ec7), gi\u1ea3m natri m\u00e1u, k\u00edch \u0111\u1ed9ng, l\u00fa l\u1eabn, tr\u1ea7m c\u1ea3m, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, nh\u00ecn m\u1edd, co th\u1eaft ph\u1ebf qu\u1ea3n, vi\u00eam mi\u1ec7ng, nhi\u1ec5m n\u1ea5m candida \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, vi\u00eam gan c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 v\u00e0ng da, r\u1ee5ng t\u00f3c, nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng, \u0111au kh\u1edbp, \u0111au c\u01a1, m\u1ec7t m\u1ecfi, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i.<\/p>\n

            R\u1ea5t hi\u1ebfm g\u1eb7p: <\/em>M\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m c\u00e1c d\u00f2ng t\u1ebf b\u00e0o m\u00e1u, n\u00f3ng n\u1ea3y, \u1ea3o gi\u00e1c, suy gan, b\u1ec7nh n\u00e3o \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e3 c\u00f3 b\u1ec7nh gan, h\u1ed3ng ban \u0111a d\u1ea1ng, h\u1ed9i ch\u1ee9ng Stevens-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, y\u1ebfu c\u01a1, vi\u00eam th\u1eadn m\u00f4 k\u1ebd, v\u00fa to \u1edf nam gi\u1edbi.<\/p>\n

            Th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/strong><\/p>\n

            \n

            T\u01af\u01a0NG T\u00c1C THU\u1ed0C:<\/strong><\/p>\n

              \n
            • Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 acid d\u1ea1 d\u00e0y trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb esomeprazole c\u00f3 th\u1ec3 l\u00e0m t\u0103ng hay gi\u1ea3m s\u1ef1 h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c n\u1ebfu c\u01a1 ch\u1ebf h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c n\u00e0y b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi n\u1ed3ng \u0111\u1ed9 acid d\u1ea1 d\u00e0y. S\u1ef1 h\u1ea5p thu c\u1ee7a ketoconazole v\u00e0 itraconazole c\u00f3 th\u1ec3 gi\u1ea3m trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi esomeprazole.<\/li>\n
            • Kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi esomeprazole v\u1edbi atazanavir v\u00ec n\u00f3 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 atazanavir trong m\u00e1u (gi\u1ea3m di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong, n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a v\u00e0 t\u1ed1i thi\u1ec3u).<\/li>\n
            • \u1ede ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, d\u00f9ng \u0111\u1ed3ng th\u1eddi esomeprazole v\u00e0 cisapride k\u1ebft qu\u1ea3 l\u00e0 l\u00e0m t\u0103ng di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong v\u00e0 k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n h\u1ee7y, nh\u01b0ng kh\u00f4ng l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a cisapride.<\/li>\n
            • Khi esomeprazole \u0111\u01b0\u1ee3c d\u00f9ng chung v\u1edbi c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a qua CYP2C19 nh\u01b0 diazepam, citalopram, imipramine, clomipramine, phenytoin…, n\u1ed3ng \u0111\u1ed9 c\u00e1c thu\u1ed1c n\u00e0y trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 t\u0103ng v\u00e0 c\u1ea7n gi\u1ea3m li\u1ec1u d\u00f9ng c\u00e1c thu\u1ed1c n\u00e0y.<\/li>\n
            • Esomeprazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP2C19 v\u00e0 CYP3A4. Khi d\u00f9ng \u0111\u1ed3ng th\u1eddi esomeprazole v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 s\u1ebd l\u00e0m t\u0103ng g\u1ea5p \u0111\u00f4i di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong c\u1ee7a esomeprazole. D\u00f9ng \u0111\u1ed3ng th\u1eddi esomeprazole c\u00f9ng v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf c\u1ea3 hai CYP2C19 v\u00e0 CYP 3A4 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng h\u01a1n hai l\u1ea7n n\u1ed3ng \u0111\u1ed9 c\u1ee7a esomeprazole. Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u esomeprazole th\u01b0\u1eddng xuy\u00ean trong nh\u1eefng t\u00ecnh hu\u1ed1ng n\u00e0y. Tuy nhi\u00ean, s\u1ef1 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u1ea7n \u0111\u01b0\u1ee3c xem x\u00e9t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng n\u1ebfu \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh.<\/li>\n
            • \u0110i\u1ec1u tr\u1ecb esomeprazole \u1edf b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng warfarin cho th\u1ea5y th\u1eddi gian \u0111\u00f4ng m\u00e1u trong m\u1ee9c ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c. Theo d\u00f5i \u0111\u01b0\u1ee3c y\u00eau c\u1ea7u khi kh\u1edfi \u0111\u1ea7u v\u00e0 k\u1ebft th\u00fac \u0111i\u1ec1u tr\u1ecb esomeprazole \u1edf b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng warfarin ho\u1eb7c c\u00e1c d\u1eabn xu\u1ea5t coumarine kh\u00e1c.<\/li>\n<\/ul>\n
              \n

              QU\u00c1 LI\u1ec0U V\u00c0 X\u1eec TR\u00cd:<\/strong><\/p>\n

              Cho \u0111\u1ebfn nay r\u1ea5t \u00edt kinh nghi\u1ec7m v\u1ec1 qu\u00e1 li\u1ec1u c\u00f3 ch\u1ee7 \u0111\u00edch. C\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c d\u00f9ng li\u1ec1u u\u1ed1ng 280 mg l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 y\u1ebfu ng\u01b0\u1eddi. C\u00e1c li\u1ec1u \u0111\u01a1n esomeprazole 80 mg ch\u01b0a g\u00e2y n\u00ean nh\u1eefng bi\u1ebfn c\u1ed1 g\u00ec. Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u n\u00e0o. Esomeprazole li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng v\u00e0 v\u00ec v\u1eady kh\u00f4ng th\u1ec3 th\u1ea9m t\u00e1ch d\u1ec5 d\u00e0ng. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, n\u00ean \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 t\u1ed5ng qu\u00e1t.<\/p>\n

              \n

              TR\u00ccNH B\u00c0Y:<\/strong><\/p>\n

              AMEPRAZOL\u00ae 20 :<\/p>\n

                \n
              • H\u1ed9p 5 v\u1ec9 x 6 vi\u00ean nang.<\/li>\n
              • H\u1ed9p 10 v\u1ec9 x 6 vi\u00ean nang.<\/li>\n<\/ul>\n

                AMEPRAZOL\u00ae 40 : H\u1ed9p 5 v\u1ec9 x 6 vi\u00ean nang.<\/p>\n

                  \n
                • H\u1ed9p 10 v\u1ec9 x 6 vi\u00ean nang.<\/li>\n
                • H\u1ed9p 2 v\u1ec9 x 7 vi\u00ean nang.<\/li>\n
                • H\u1ed9p 4 v\u1ec9 x 7 vi\u00ean nang.<\/li>\n<\/ul>\n

                  B\u1ea2O QU\u1ea2N: B\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 t\u1eeb 150C \u0111\u1ebfn 250C, n\u01a1i kh\u00f4 r\u00e1o.<\/p>\n

                  H\u1ea0N D\u00d9NG: 24 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t. Kh\u00f4ng d\u00f9ng thu\u1ed1c khi qu\u00e1 h\u1ea1n s\u1eed d\u1ee5ng<\/p>\n","protected":false},"excerpt":{"rendered":"

                  TH\u00c0NH PH\u1ea6N: Vi\u00ean nang AMEPRAZOL\u00ae 20 : M\u1ed7i vi\u00ean nang ch\u1ee9a: Esomeprazole…………………………… 20 mg ( d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t tan trong ru\u1ed9t ch\u1ee9a 8,5% (kl\/kl) Esomeprazole magnesi) Vi\u00ean nang AMEPRAZOL\u00ae 40 : M\u1ed7i vi\u00ean nang ch\u1ee9a: Esomeprazole…………………………… 40 mg ( d\u01b0\u1edbi d\u1ea1ng vi h\u1ea1t tan trong ru\u1ed9t ch\u1ee9a 8,5% (kl\/kl) Esomeprazole magnesi ) D\u01af\u1ee2C L\u1ef0C…<\/p>\n","protected":false},"featured_media":867,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_cat":[58],"product_tag":[],"class_list":["post-980","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-alimentary-system-drugs"],"_links":{"self":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product\/980","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/comments?post=980"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media\/867"}],"wp:attachment":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media?parent=980"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_cat?post=980"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_tag?post=980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}