Thu\u1ed1c n\u00e0y ch\u1ec9 d\u00f9ng theo \u0111\u01a1n thu\u1ed1c
\n\u0110\u1ec3 xa t\u1ea7m tay tr\u1ebb em
\n\u0110\u1ecdc k\u1ef9 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi d\u00f9ng<\/p>\n
TH\u00c0NH PH\u1ea6N C\u00d4NG TH\u1ee8C THU\u1ed0C: M\u1ed7i vi\u00ean n\u00e9n nhai ch\u1ee9a:<\/p>\n
Th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t:<\/p>\n
Bismuth subsalicylate\u2026\u2026\u2026\u2026\u2026\u2026\u2026.262 mg.<\/p>\n
Th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c:<\/p>\n
Calci carbonat light, mannitol 60, povidon K30, natri saccharin, ponceau 4R lake, erythrosin red, menthol, b\u1ed9t h\u01b0\u01a1ng x\u00e1 x\u1ecb, talc, magnesi stearat.<\/p>\n
D\u1ea0NG B\u00c0O CH\u1ebe:<\/p>\n
Vi\u00ean n\u00e9n nhai.<\/p>\n
Vi\u00ean n\u00e9n tr\u00f2n, m\u00e0u h\u1ed3ng, m\u1ed9t m\u1eb7t tr\u01a1n, m\u1ed9t m\u1eb7t c\u00f3 v\u1ea1ch ngang chia \u0111\u00f4i vi\u00ean, m\u00f9i x\u00e1 x\u1ecb, v\u1ecb ng\u1ecdt m\u00e1t.<\/p>\n
CH\u1ec8 \u0110\u1ecaNH:<\/p>\n
L\u00e0m gi\u1ea3m ti\u00eau ch\u1ea3y du l\u1ecbch, ti\u00eau ch\u1ea3y, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a do \u0103n u\u1ed1ng qu\u00e1 \u0111\u1ed9 nh\u01b0 \u1ee3 n\u00f3ng, kh\u00f3 ti\u00eau, bu\u1ed3n n\u00f4n, \u1ee3 h\u01a1i, ch\u01b0\u1edbng b\u1ee5ng.<\/p>\n
C\u00c1CH D\u00d9NG, LI\u1ec0U D\u00d9NG:<\/p>\n
C\u00e1ch d\u00f9ng: Nhai vi\u00ean thu\u1ed1c.<\/p>\n
Li\u1ec1u d\u00f9ng:<\/p>\n
Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean: 2 vi\u00ean\/l\u1ea7n.<\/p>\n
C\u00f3 th\u1ec3 d\u00f9ng l\u1eb7p l\u1ea1i li\u1ec1u tr\u00ean m\u1ed7i \u00bd – 1 gi\u1edd n\u1ebfu c\u1ea7n. Kh\u00f4ng d\u00f9ng qu\u00e1 8 li\u1ec1u (16 vi\u00ean) trong 24 gi\u1edd.<\/p>\n
S\u1eed d\u1ee5ng cho \u0111\u1ebfn khi ng\u1eebng ti\u00eau ch\u1ea3y nh\u01b0ng kh\u00f4ng qu\u00e1 2 ng\u00e0y. C\u1ea7n u\u1ed1ng \u0111\u1ee7 n\u01b0\u1edbc \u0111\u1ec3 ng\u0103n ng\u1eeba m\u1ea5t n\u01b0\u1edbc do ti\u00eau ch\u1ea3y.<\/p>\n
CH\u1ed0NG CH\u1ec8 \u0110\u1ecaNH:<\/p>\n
Qu\u00e1 m\u1eabn v\u1edbi bismuth subsalicylate ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n
Qu\u00e1 m\u1eabn v\u1edbi aspirin hay c\u00e1c thu\u1ed1c salicylate kh\u00e1c.<\/p>\n
B\u1ec7nh nh\u00e2n b\u1ecb vi\u00eam lo\u00e9t, r\u1ed1i lo\u1ea1n ch\u1ea3y m\u00e1u, ph\u00e2n c\u00f3 m\u00e1u ho\u1eb7c ph\u00e2n \u0111en.<\/p>\n
Tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i.<\/p>\n
C\u1ea2NH B\u00c1O V\u00c0 TH\u1eacN TR\u1eccNG KHI D\u00d9NG THU\u1ed0C:<\/p>\n
AMEBISMO c\u00f3 ch\u1ee9a salicylate, n\u1ebfu d\u00f9ng thu\u1ed1c k\u00e8m v\u1edbi aspirin m\u00e0 xu\u1ea5t hi\u1ec7n ch\u1ee9ng \u00f9 tai, n\u00ean ng\u01b0ng d\u00f9ng thu\u1ed1c.<\/p>\n
AMEBISMO kh\u00f4ng ch\u1ee9a aspirin, nh\u01b0ng n\u1ebfu \u0111\u00e3 t\u1eebng b\u1ecb d\u1ecb \u1ee9ng v\u1edbi aspirin ho\u1eb7c v\u1edbi c\u00e1c salicylate kh\u00e1c kh\u00f4ng ch\u1ee9a aspirin th\u00ec kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c v\u00ec c\u00f3 th\u1ec3 x\u1ea3y ra nh\u1eefng ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n.<\/p>\n
N\u1ebfu ti\u00eau ch\u1ea3y c\u00f3 k\u00e8m s\u1ed1t cao ho\u1eb7c k\u00e9o d\u00e0i h\u01a1n 2 ng\u00e0y, n\u00ean \u0111i kh\u00e1m b\u00e1c s\u0129.<\/p>\n
Kh\u00f4ng d\u00f9ng thu\u1ed1c n\u00e0y cho tr\u1ebb em v\u00e0 thi\u1ebfu ni\u00ean \u0111ang m\u1eafc b\u1ec7nh th\u1ee7y \u0111\u1eadu hay c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng gi\u1ed1ng c\u00fam ho\u1eb7c v\u1eeba ph\u1ee5c h\u1ed3i kh\u1ecfi 2 b\u1ec7nh tr\u00ean.<\/p>\n
N\u1ebfu bu\u1ed3n n\u00f4n hay n\u00f4n x\u1ea3y ra khi \u0111ang d\u00f9ng thu\u1ed1c n\u00e0y th\u00ec c\u1ea7n \u0111i kh\u00e1m b\u00e1c s\u0129 v\u00ec c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y c\u00f3 th\u1ec3 l\u00e0 d\u1ea5u hi\u1ec7u s\u1edbm c\u1ee7a h\u1ed9i ch\u1ee9ng Reye, m\u1ed9t b\u1ec7nh c\u1ea3nh nghi\u00eam tr\u1ecdng nh\u01b0ng hi\u1ebfm g\u1eb7p.<\/p>\n
B\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn.<\/p>\n
B\u1ec7nh gan n\u1eb7ng c\u00f3 th\u1ec3 g\u00e2y t\u00edch l\u0169y bismuth.<\/p>\n
Thu\u1ed1c n\u00e0y c\u00f3 ch\u1ee9a: Ponceau 4R lake, c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng<\/p>\n
S\u1eec D\u1ee4NG THU\u1ed0C CHO PH\u1ee4 N\u1eee C\u00d3 THAI V\u00c0 CHO CON B\u00da:<\/p>\n
Ch\u01b0a c\u00f3 s\u1ed1 li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c \u1edf ph\u1ee5 n\u1eef mang thai.<\/p>\n
C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng \u0111\u1ee7 \u0111\u1ed1i v\u1edbi thai k\u1ef3, s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ph\u00f4i\/thai, sinh \u0111\u1ebb v\u00e0 ph\u00e1t tri\u1ec3n sau sinh. Ch\u01b0a r\u00f5 nh\u1eefng nguy c\u01a1 ti\u1ec1m \u1ea9n \u0111\u1ed1i v\u1edbi con ng\u01b0\u1eddi.<\/p>\n
Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng bismuth subsalicylate trong khi mang thai v\u00e0 cho con b\u00fa tr\u1eeb khi th\u1eadt c\u1ea7n thi\u1ebft.<\/p>\n
\u1ea2NH H\u01af\u1edeNG C\u1ee6A THU\u1ed0C L\u00caN KH\u1ea2 N\u0102NG L\u00c1I XE, V\u1eacN H\u00c0NH M\u00c1Y M\u00d3C:<\/p>\n
Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng.<\/p>\n
T\u01af\u01a0NG T\u00c1C, T\u01af\u01a0NG K\u1ef4 C\u1ee6A THU\u1ed0C:<\/p>\n
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c:<\/p>\n
Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u: Mu\u1ed1i salicylate (bismuth subsalicylate) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u. C\u1ea7n theo d\u00f5i vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng \u0111\u00f4ng, \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng khi c\u1ea7n thi\u1ebft.<\/p>\n
Thu\u1ed1c ch\u1eefa b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng: T\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u00f3 th\u1ec3 t\u0103ng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi mu\u1ed1i salicylate. C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng k\u1ebft h\u1ee3p.<\/p>\n
Ciprofloxacin: Bismuth subsalicylate l\u00e0m gi\u1ea3m nh\u1eb9 n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 AUC c\u1ee7a ciprofloxacin.<\/p>\n
Doxycycline: Bismuth subsalicylate l\u00e0m gi\u1ea3m s\u1ef1 h\u1ea5p thu c\u1ee7a doxycycline. Tr\u00e1nh d\u00f9ng bismuth subsalicylate \u0111\u1ec3 t\u1ef1 \u0111i\u1ec1u tr\u1ecb \u0111\u1ed1i v\u1edbi du kh\u00e1ch \u0111ang d\u00f9ng doxycycline \u0111\u1ec3 d\u1ef1 ph\u00f2ng s\u1ed1t r\u00e9t.<\/p>\n
Tetracycline: Kh\u1ea3 n\u0103ng h\u1ea5p thu kh\u00e1ng sinh tetracycline c\u00f3 th\u1ec3 gi\u1ea3m khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 ch\u1ee9a bismuth m\u1eb7c d\u00f9 s\u1ef1 t\u01b0\u01a1ng t\u00e1c n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3m thi\u1ec3u b\u1eb1ng c\u00e1ch u\u1ed1ng hai thu\u1ed1c n\u00e0y c\u00e1ch nhau v\u00e0i gi\u1edd.<\/p>\n
T\u01b0\u01a1ng k\u1ef5 thu\u1ed1c: Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n
T\u00c1C D\u1ee4NG KH\u00d4NG MONG MU\u1ed0N C\u1ee6A THU\u1ed0C:<\/p>\n
Th\u01b0\u1eddng g\u1eb7p, ADR>1\/100<\/p>\n
Nhu\u1ed9m \u0111en ph\u00e2n ho\u1eb7c l\u01b0\u1ee1i, l\u00e0m bi\u1ebfn m\u00e0u r\u0103ng (c\u00f3 ph\u1ee5c h\u1ed3i)<\/p>\n
\u00cdt g\u1eb7p, 1\/1000<ADR<1\/100<\/p>\n
Bu\u1ed3n n\u00f4n, n\u00f4n.<\/p>\n
Hi\u1ebfm g\u1eb7p, ADR<1\/1000<\/p>\n
\u0110\u1ed9c t\u00ednh th\u1eadn, b\u1ec7nh n\u00e3o, \u0111\u1ed9c t\u00ednh th\u1ea7n kinh.<\/p>\n
Th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129 nh\u1eefng ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n
QU\u00c1 LI\u1ec0U V\u00c0 C\u00c1CH X\u1eec TR\u00cd:<\/p>\n
Bismuth<\/p>\n
Ng\u1ed9 \u0111\u1ed9c bismuth c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n d\u01b0\u1edbi d\u1ea1ng b\u1ec7nh n\u00e3o c\u1ea5p t\u00ednh v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00fa l\u1eabn, gi\u1eadt c\u01a1, run, lo\u1ea1n v\u1eadn ng\u00f4n, r\u1ed1i lo\u1ea1n \u0111i v\u00e0 \u0111\u1ee9ng. Ng\u1ed9 \u0111\u1ed9c bismuth c\u0169ng c\u00f3 th\u1ec3 g\u00e2y r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, ph\u1ea3n \u1ee9ng tr\u00ean da, \u0111\u1ed5i m\u00e0u m\u00e0ng nh\u1ea7y, v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn do ho\u1ea1i t\u1eed \u1ed1ng th\u1eadn c\u1ea5p t\u00ednh. \u0110i\u1ec1u tr\u1ecb bao g\u1ed3m r\u1eeda d\u1ea1 d\u00e0y, t\u1ea9y x\u1ed5 v\u00e0 b\u00f9 n\u01b0\u1edbc. Ch\u1ea5t t\u1ea1o ph\u1ee9c chelat c\u00f3 th\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 trong giai \u0111o\u1ea1n \u0111\u1ea7u sau khi u\u1ed1ng v\u00e0 th\u1ea9m t\u00e1ch m\u00e1u c\u00f3 th\u1ec3 l\u00e0 c\u1ea7n thi\u1ebft.<\/p>\n
Salicylate:<\/p>\n
Qu\u00e1 li\u1ec1u c\u1ee7a Amebismo c\u0169ng c\u00f3 th\u1ec3 g\u00e2y tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c salicylate. Ng\u1ed9 \u0111\u1ed9c salicylate th\u01b0\u1eddng li\u00ean quan v\u1edbi n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng > 350 mg\/L (2,5 mmol\/L). H\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p t\u1eed vong \u1edf ng\u01b0\u1eddi l\u1edbn x\u1ea3y ra \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 n\u1ed3ng \u0111\u1ed9 v\u01b0\u1ee3t qu\u00e1 700 mg\/L (5,1 mmol\/L). Li\u1ec1u \u0111\u01a1n d\u01b0\u1edbi 100 mg\/kg kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ng\u1ed9 \u0111\u1ed9c nghi\u00eam tr\u1ecdng.<\/p>\n
N\u1ebfu c\u00e1c tri\u1ec7u ch\u1ee9ng x\u1ea3y ra, n\u00ean ng\u01b0ng s\u1eed d\u1ee5ng Amebismo. X\u1eed tr\u00ed qu\u00e1 li\u1ec1u c\u0169ng gi\u1ed1ng nh\u01b0 c\u00e1ch x\u1eed tr\u00ed qu\u00e1 li\u1ec1u salicylate:<\/p>\n
C\u00e1c tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng g\u1eb7p bao g\u1ed3m n\u00f4n m\u1eeda, m\u1ea5t n\u01b0\u1edbc, \u00f9 tai, ch\u00f3ng m\u1eb7t, \u0111i\u1ebfc, \u0111\u1ed5 m\u1ed3 h\u00f4i, t\u1ee9 chi \u1ea5m k\u00e8m m\u1ea1ch d\u1ed9i, t\u0103ng nh\u1ecbp th\u1edf v\u00e0 t\u0103ng th\u00f4ng kh\u00ed ph\u1ed5i. M\u1ed9t v\u00e0i m\u1ee9c \u0111\u1ed9 r\u1ed1i lo\u1ea1n acid-base hi\u1ec7n di\u1ec7n trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p.<\/p>\n
Ch\u1ee9ng nhi\u1ec5m ki\u1ec1m h\u00f4 h\u1ea5p v\u00e0 nhi\u1ec5m toan chuy\u1ec3n h\u00f3a h\u1ed7n h\u1ee3p v\u1edbi pH \u0111\u1ed9ng m\u1ea1ch b\u00ecnh th\u01b0\u1eddng ho\u1eb7c cao (n\u1ed3ng \u0111\u1ed9 ion hydro b\u00ecnh th\u01b0\u1eddng ho\u1eb7c gi\u1ea3m) th\u01b0\u1eddng x\u1ea3y ra \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 4 tu\u1ed5i. \u1ede tr\u1ebb em t\u1eeb 4 tu\u1ed5i tr\u1edf xu\u1ed1ng, ch\u1ee9ng nhi\u1ec5m toan chuy\u1ec3n h\u00f3a chi\u1ebfm \u01b0u th\u1ebf v\u1edbi pH \u0111\u1ed9ng m\u1ea1ch th\u1ea5p (t\u0103ng n\u1ed3ng \u0111\u1ed9 ion hydro) l\u00e0 ph\u1ed5 bi\u1ebfn. Nhi\u1ec5m acid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng s\u1ef1 v\u1eadn chuy\u1ec3n salicylate qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o.<\/p>\n
C\u00e1c tri\u1ec7u ch\u1ee9ng \u00edt g\u1eb7p bao g\u1ed3m n\u00f4n ra m\u00e1u, s\u1ed1t cao, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, h\u1ea1 kali huy\u1ebft, gi\u1ea3m ti\u1ec3u c\u1ea7u, t\u0103ng INR\/PTR, \u0111\u00f4ng m\u00e1u n\u1ed9i m\u1ea1ch, suy th\u1eadn v\u00e0 ph\u00f9 ph\u1ed5i kh\u00f4ng do tim.<\/p>\n
C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng bao g\u1ed3m l\u00fa l\u1eabn, m\u1ea5t ph\u01b0\u01a1ng h\u01b0\u1edbng, h\u00f4n m\u00ea v\u00e0 co gi\u1eadt \u00edt g\u1eb7p h\u01a1n \u1edf ng\u01b0\u1eddi l\u1edbn so v\u1edbi tr\u1ebb em.<\/p>\n
X\u1eed tr\u00ed: D\u00f9ng than ho\u1ea1t t\u00ednh n\u1ebfu ng\u01b0\u1eddi l\u1edbn s\u1eed d\u1ee5ng qu\u00e1 250 mg\/kg bi\u1ec3u l\u1ed9 trong v\u00f2ng m\u1ed9t gi\u1edd. N\u00ean x\u00e1c \u0111\u1ecbnh n\u1ed3ng \u0111\u1ed9 salicylate huy\u1ebft t\u01b0\u01a1ng, m\u1eb7c d\u00f9 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a ng\u1ed9 \u0111\u1ed9c kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh ch\u1ec9 t\u1eeb \u0111i\u1ec1u n\u00e0y v\u00e0 ph\u1ea3i t\u00ednh \u0111\u1ebfn c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 sinh h\u00f3a. T\u0103ng th\u1ea3i tr\u1eeb do ki\u1ec1m h\u00f3a n\u01b0\u1edbc ti\u1ec3u b\u1eb1ng c\u00e1ch d\u00f9ng natri bicarbonat 1,26%. N\u00ean theo d\u00f5i pH n\u01b0\u1edbc ti\u1ec3u. \u0110i\u1ec1u ch\u1ec9nh nhi\u1ec5m toan chuy\u1ec3n h\u00f3a b\u1eb1ng natri bicarbonat 8,4% ti\u00eam t\u0129nh m\u1ea1ch (ki\u1ec3m tra tr\u01b0\u1edbc kali huy\u1ebft thanh). Kh\u00f4ng n\u00ean d\u00f9ng l\u1ee3i ti\u1ec3u c\u01b0\u1ee1ng b\u1ee9c v\u00ec kh\u00f4ng l\u00e0m t\u0103ng b\u00e0i ti\u1ebft salicylate v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ph\u00f9 ph\u1ed5i.<\/p>\n
Th\u1ea9m ph\u00e2n m\u00e1u l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb l\u1ef1a ch\u1ecdn cho ng\u1ed9 \u0111\u1ed9c n\u1eb7ng v\u00e0 n\u00ean \u0111\u01b0\u1ee3c xem x\u00e9t cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 n\u1ed3ng \u0111\u1ed9 salicylate huy\u1ebft t\u01b0\u01a1ng > 700 mg\/L (5,1 mmol\/l) ho\u1eb7c n\u1ed3ng \u0111\u1ed9 th\u1ea5p h\u01a1n c\u00f3 k\u00e8m c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng ho\u1eb7c chuy\u1ec3n h\u00f3a n\u1eb7ng. B\u1ec7nh nh\u00e2n d\u01b0\u1edbi 10 tu\u1ed5i ho\u1eb7c tr\u00ean 70 tu\u1ed5i t\u0103ng nguy c\u01a1 nhi\u1ec5m \u0111\u1ed9c salicylate v\u00e0 c\u00f3 th\u1ec3 c\u1ea7n l\u1ecdc m\u00e1u \u1edf giai \u0111o\u1ea1n s\u1edbm h\u01a1n.<\/p>\n
D\u01af\u1ee2C L\u1ef0C H\u1eccC:<\/p>\n
Nh\u00f3m d\u01b0\u1ee3c l\u00fd: Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ti\u00eau ch\u1ea3y, vi\u00eam nhi\u1ec5m \u0111\u01b0\u1eddng ru\u1ed9t\/Ch\u1ea5t h\u1ea5p ph\u1ee5 \u0111\u01b0\u1eddng ru\u1ed9t<\/p>\n
M\u00e3 ATC: A07B B<\/p>\n
– Bismuth subsalicylate c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y, g\u1eafn v\u00e0o ch\u1ed7 lo\u00e9t v\u00e0 ni\u00eam m\u1ea1c, g\u1eafn acid m\u1eadt, gi\u1ea3m prostaglandin n\u1ed9i sinh v\u00e0 bicarbonate.<\/p>\n
– Bismuth subsalicylate l\u00e0m gi\u1ea3m s\u1ed1 l\u1ea7n \u0111i ti\u00eau, l\u00e0m ph\u00e2n s\u0103n ch\u1eafc, b\u00ecnh th\u01b0\u1eddng h\u00f3a s\u1ef1 di chuy\u1ec3n ch\u1ea5t l\u1ecfng th\u00f4ng qua c\u01a1 ch\u1ebf kh\u00e1ng ti\u1ebft, li\u00ean k\u1ebft \u0111\u1ed9c t\u1ed1 c\u1ee7a vi khu\u1ea9n, v\u00e0 th\u1ec3 hi\u1ec7n ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n \u1edf b\u1ec7nh nh\u00e2n b\u1ecb ti\u00eau ch\u1ea3y.<\/p>\n
D\u01af\u1ee2C \u0110\u1ed8NG H\u1eccC:<\/p>\n
– Bismuth subsalicylate \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i th\u00e0nh bismuth carbonate v\u00e0 natri salicylate \u1edf ru\u1ed9t non.<\/p>\n
– Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a bismuth subsalicylate r\u1ea5t th\u1ea5p. Kh\u1ea3 n\u0103ng ph\u00e2n b\u1ed1 c\u1ee7a bismuth trong c\u00e1c m\u00f4 c\u1ee7a c\u01a1 th\u1ec3 ng\u01b0\u1eddi r\u1ea5t \u00edt. M\u1eb7c d\u00f9 bismuth c\u0169ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua m\u1eadt, nh\u01b0ng thanh th\u1ea3i qua th\u1eadn l\u00e0 con \u0111\u01b0\u1eddng b\u00e0i ti\u1ebft nguy\u00ean ph\u00e1t c\u1ee7a bismuth. Ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua ph\u00e2n d\u01b0\u1edbi d\u1ea1ng mu\u1ed1i bismuth kh\u00f4ng h\u00f2a tan. Sau khi u\u1ed1ng li\u1ec1u khuy\u1ebfn c\u00e1o h\u1eb1ng ng\u00e0y t\u1ed1i \u0111a cho ng\u01b0\u1eddi l\u1edbn, th\u1eddi gian b\u00e1n h\u1ee7y sinh h\u1ecdc trung b\u00ecnh kho\u1ea3ng 33 gi\u1edd v\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a bismuth trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t d\u01b0\u1edbi 35ppb.<\/p>\n
Salicylate h\u1ea5p thu qua ru\u1ed9t v\u00e0 nhanh ch\u00f3ng ph\u00e2n b\u1ed1 v\u00e0o trong c\u00e1c m\u00f4 c\u1ee7a c\u01a1 th\u1ec3. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau li\u1ec1u d\u00f9ng t\u1ed1i \u0111a h\u1eb1ng ng\u00e0y kho\u1ea3ng 110 microgram\/ml. Salicylate \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft nhanh ra kh\u1ecfi c\u01a1 th\u1ec3 v\u00e0 th\u1eddi gian b\u00e1n h\u1ee7y sinh h\u1ecdc trung b\u00ecnh kho\u1ea3ng 4-5,5 gi\u1edd.<\/p>\n
QUY C\u00c1CH \u0110\u00d3NG G\u00d3I:<\/p>\n
H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean n\u00e9n nhai.<\/p>\n
H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean n\u00e9n nhai.<\/p>\n
H\u1ed9p 6 v\u1ec9 x 4 vi\u00ean n\u00e9n nhai.<\/p>\n
\u0110I\u1ec0U KI\u1ec6N B\u1ea2O QU\u1ea2N, H\u1ea0N D\u00d9NG, TI\u00caU CHU\u1ea8N CH\u1ea4T L\u01af\u1ee2NG C\u1ee6A THU\u1ed0C:<\/p>\n
B\u1ea3o qu\u1ea3n: \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 300C, n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n
H\u1ea1n d\u00f9ng: 36 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t. Kh\u00f4ng d\u00f9ng thu\u1ed1c khi qu\u00e1 h\u1ea1n d\u00f9ng.<\/p>\n
Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a thu\u1ed1c: TCCS<\/p>\n
T\u00caN, \u0110\u1ecaA CH\u1ec8 C\u1ee6A C\u01a0 S\u1ede S\u1ea2N XU\u1ea4T THU\u1ed0C:<\/p>\n
C\u00d4NG TY C\u1ed4 PH\u1ea6N D\u01af\u1ee2C PH\u1ea8M OPV<\/p>\n
S\u1ed1 27, \u0110\u01b0\u1eddng 3A, Khu C\u00f4ng Nghi\u1ec7p Bi\u00ean H\u00f2a II, Ph\u01b0\u1eddng An B\u00ecnh, Tp. Bi\u00ean H\u00f2a, T\u1ec9nh \u0110\u1ed3ng Nai.<\/p>\n
\u0110T: (0251) 3992999 Fax: (0251) 3892344<\/p>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c n\u00e0y ch\u1ec9 d\u00f9ng theo \u0111\u01a1n thu\u1ed1c \u0110\u1ec3 xa t\u1ea7m tay tr\u1ebb em \u0110\u1ecdc k\u1ef9 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi d\u00f9ng TH\u00c0NH PH\u1ea6N C\u00d4NG TH\u1ee8C THU\u1ed0C: M\u1ed7i vi\u00ean n\u00e9n nhai ch\u1ee9a: Th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t: Bismuth subsalicylate\u2026\u2026\u2026\u2026\u2026\u2026\u2026.262 mg. Th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c: Calci carbonat light, mannitol 60, povidon K30, natri saccharin, ponceau 4R lake,…<\/p>\n","protected":false},"featured_media":799,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_cat":[24],"product_tag":[],"class_list":["post-978","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-otc"],"_links":{"self":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product\/978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/comments?post=978"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media\/799"}],"wp:attachment":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media?parent=978"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_cat?post=978"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_tag?post=978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}