{"id":1019,"date":"2026-05-19T09:51:55","date_gmt":"2026-05-19T02:51:55","guid":{"rendered":"https:\/\/opv.vn\/?post_type=product&p=1019"},"modified":"2026-05-19T09:51:55","modified_gmt":"2026-05-19T02:51:55","slug":"tydol-plus","status":"publish","type":"product","link":"https:\/\/opv.vn\/en\/tydol-plus\/","title":{"rendered":"TYDOL\u00ae Plus"},"content":{"rendered":"

TYDOL\u00ae<\/sup> Plus<\/strong><\/p>\n

\u0110\u1ec3\u00a0<\/strong>xa t\u1ea7m tay tr\u1ebb em<\/strong><\/p>\n

\u0110<\/strong>\u1ecdc k\u1ef9 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi d\u00f9ng<\/strong><\/p>\n

T<\/strong>h\u00f4ng b\u00e1o ngay cho b\u00e1c s\u1ef9 ho\u1eb7c d\u01b0\u1ee3c s\u1ef9 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu<\/strong>\u1ed1<\/strong>n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c<\/strong>.<\/strong><\/p>\n

PH\u1ea6N I.<\/strong> H<\/strong>\u01af\u1edaNG D\u1eaaN S\u1eec D\u1ee4NG THU\u1ed0C CHO NG\u01af\u1edcI B\u1ec6NH<\/strong><\/h2>\n

TH\u00c0NH PH\u1ea6N, H\u00c0M L\u01af\u1ee2NG C\u1ee6A THU\u1ed0C<\/strong>: <\/strong>M\u1ed7i vi\u00ean n\u00e9n bao phim ch\u1ee9a:<\/h3>\n
    \n
  • Ho\u1ea1t ch\u1ea5t: <\/em>Acetaminophen……………………….. 500 mg<\/li>\n<\/ul>\n

    Cafein…………………………………………… 65 mg<\/p>\n

      \n
    • T\u00e1 d\u01b0\u1ee3c:<\/em> Tinh b\u1ed9t ti\u1ec1n h\u1ed3 ho\u00e1, lactose monohydrat, silic oxyd d\u1ea1ng keo khan, natri starch glycolat, tinh b\u1ed9t ng\u00f4, povidon K30, talc, magnesi stearat, opadry II white, ponceau 4R lake.<\/li>\n<\/ul>\n

      M\u00d4 T\u1ea2 S\u1ea2N PH\u1ea8M<\/strong><\/h3>\n

      Vi\u00ean n\u00e9n bao phim, h\u00ecnh thu\u00f4n d\u00e0i, m\u00e0u h\u1ed3ng, c\u00f3 in ch\u1eef \u201cTydolPlus<\/strong>\u201d m\u00e0u \u0111en tr\u00ean hai m\u1eb7t vi\u00ean, c\u1ea1nh v\u00e0 th\u00e0nh vi\u00ean l\u00e0nh l\u1eb7n.<\/p>\n

      QUY C\u00c1CH \u0110\u00d3NG G\u00d3I<\/strong><\/h3>\n
      – H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean n\u00e9n bao phim.<\/h5>\n
      – H\u1ed9p 1 chai x 100 vi\u00ean n\u00e9n bao phim.<\/h5>\n

      THU\u1ed0C D\u00d9NG CHO B\u1ec6NH G\u00cc<\/strong><\/h3>\n

      Gi\u1ea3m \u0111au nh\u1eb9 trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p<\/h4>\n

      – Nh\u1ee9c \u0111\u1ea7u, nh\u1ee9c r\u0103ng, \u0111au c\u01a1, vi\u00eam xoang.<\/p>\n

      – \u0110au nh\u1ee9c do th\u1ea5p kh\u1edbp.<\/p>\n

      – \u0110au b\u1ee5ng kinh.<\/p>\n

      – C\u1ea3m l\u1ea1nh th\u00f4ng th\u01b0\u1eddng.<\/p>\n

      H\u1ea1 s\u1ed1t.<\/p>\n

      N\u00caN D\u00d9NG THU\u1ed0C N\u00c0Y NH\u01af TH\u1ebe N\u00c0O V\u00c0 LI\u1ec0U L\u01af\u1ee2NG<\/strong><\/h3>\n

      C\u00e1ch d\u00f9ng:<\/em><\/strong> Thu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n

      Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n

      Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i: U\u1ed1ng 1 – 2 vi\u00ean m\u1ed7i 6 gi\u1edd khi c\u00e1c tri\u1ec7u ch\u1ee9ng k\u00e9o d\u00e0i. Kh\u00f4ng d\u00f9ng qu\u00e1 8 vi\u00ean \/ 24 gi\u1edd ho\u1eb7c theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/p>\n

      KHI N\u00c0O KH\u00d4NG N\u00caN D\u00d9NG THU\u1ed0C N\u00c0Y<\/strong><\/h3>\n

      – Ng\u01b0\u1eddi b\u1ec7nh qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n

      – B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n

      – Ng\u01b0\u1eddi b\u1ec7nh thi\u1ebfu h\u1ee5t glucose-6-phosphat dehydrogenase.<\/p>\n

      – Tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i.<\/p>\n

      T\u00c1C D\u1ee4NG KH\u00d4NG MONG MU\u1ed0N<\/strong><\/h3>\n

      – Ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng nh\u01b0 h\u1ed9i ch\u1ee9ng Steven-Johnson, h\u1ed9i ch\u1ee9ng Lyell, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, m\u1ee5n m\u1ee7 ban \u0111\u1ecf to\u00e0n th\u00e2n c\u1ea5p tuy hi\u1ebfm x\u1ea3y ra, nh\u01b0ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u1eed vong. N\u1ebfu th\u1ea5y xu\u1ea5t hi\u1ec7n ban ho\u1eb7c c\u00e1c bi\u1ec3u hi\u1ec7n kh\u00e1c v\u1ec1 da, ph\u1ea3i ng\u1eebng d\u00f9ng thu\u1ed1c v\u00e0 th\u0103m kh\u00e1m th\u1ea7y thu\u1ed1c.<\/p>\n

      – Ban da v\u00e0 nh\u1eefng ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng kh\u00e1c th\u1ec9nh tho\u1ea3ng x\u1ea3y ra. Th\u01b0\u1eddng l\u00e0 ban \u0111\u1ecf ho\u1eb7c m\u00e0y \u0111ay, nh\u01b0ng \u0111\u00f4i khi n\u1eb7ng h\u01a1n v\u00e0 c\u00f3 th\u1ec3 k\u00e8m theo s\u1ed1t do thu\u1ed1c v\u00e0 th\u01b0\u01a1ng t\u1ed5n ni\u00eam m\u1ea1c. N\u1ebfu th\u1ea5y s\u1ed1t, b\u1ecdng n\u01b0\u1edbc quanh c\u00e1c h\u1ed1c t\u1ef1 nhi\u00ean, n\u00ean ngh\u0129 \u0111\u1ebfn h\u1ed9i ch\u1ee9ng Steven-Johnson, ph\u1ea3i ng\u1eebng thu\u1ed1c ngay. Qu\u00e1 li\u1ec1u acetaminophen c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng gan n\u1eb7ng v\u00e0 \u0111\u00f4i khi ho\u1ea1i t\u1eed \u1ed1ng th\u1eadn c\u1ea5p. Ng\u01b0\u1eddi b\u1ec7nh m\u1eabn c\u1ea3m v\u1edbi salicylat hi\u1ebfm khi m\u1eabn c\u1ea3m v\u1edbi acetaminophen v\u00e0 nh\u1eefng thu\u1ed1c c\u00f3 li\u00ean quan. Trong m\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p ri\u00eang l\u1ebb, acetaminophen \u0111\u00e3 g\u00e2y gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u.<\/p>\n

      – Th\u1ea7n kinh trung \u01b0\u01a1ng: K\u00edch \u0111\u1ed9ng, ch\u00f3ng m\u1eb7t.<\/p>\n

      – \u00cdt g\u1eb7p:<\/em><\/p>\n

      Da: Ban<\/p>\n

      D\u1ea1 d\u00e0y \u2013 ru\u1ed9t: Bu\u1ed3n n\u00f4n, n\u00f4n.<\/p>\n

      Huy\u1ebft h\u1ecdc: Lo\u1ea1n t\u1ea1o m\u00e1u (gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u), thi\u1ebfu m\u00e1u.<\/p>\n

      Th\u1eadn: B\u1ec7nh th\u1eadn, \u0111\u1ed9c t\u00ednh th\u1eadn khi l\u1ea1m d\u1ee5ng d\u00e0i ng\u00e0y.<\/p>\n

      – Hi\u1ebfm g\u1eb7p:<\/em><\/p>\n

      Da: H\u1ed9i ch\u1ee9ng Steven-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, h\u1ed9i ch\u1ee9ng Lyell, m\u1ee5n m\u1ee7 ngo\u1ea1i ban to\u00e0n th\u00e2n c\u1ea5p t\u00ednh.<\/p>\n

      Kh\u00e1c: Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn.<\/p>\n

      N\u00caN TR\u00c1NH D\u00d9NG NH\u1eeeNG THU\u1ed0C HO\u1eb6C TH\u1ef0C PH\u1ea8M G\u00cc KHI \u0110ANG S\u1eec D\u1ee4NG THU\u1ed0C N\u00c0Y<\/strong><\/h3>\n

      – Metoclopramid ho\u1eb7c domperidon<\/p>\n

      – Colestyramin.<\/p>\n

      – Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u coumarin v\u00e0 d\u1eabn ch\u1ea5t indandion.<\/p>\n

      – Phenothiazin v\u00e0 li\u1ec7u ph\u00e1p h\u1ea1 nhi\u1ec7t (nh\u01b0 acetaminophen).<\/p>\n

      – R\u01b0\u1ee3u.<\/p>\n

      – C\u00e1c thu\u1ed1c ch\u1ed1ng co gi\u1eadt (g\u1ed3m phenytoin, barbiturat, carbamazepin), isoniazid, c\u00e1c thu\u1ed1c ch\u1ed1ng lao.<\/p>\n

      – Probenecid.<\/p>\n

      – C\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP1A2 (nh\u01b0 clozapin) ho\u1eb7c c\u00e1c thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng ho\u1eb7c \u1ee9c ch\u1ebf CYP1A2.<\/p>\n

      C\u1ea6N L\u00c0M G\u00cc KHI M\u1ed8T L\u1ea6N QU\u00caN KH\u00d4NG D\u00d9NG THU\u1ed0C<\/strong><\/h3>\n

      N\u1ebfu b\u1ea1n qu\u00ean d\u00f9ng thu\u1ed1c, d\u00f9ng n\u00f3 ngay khi b\u1ea1n nh\u1edb. N\u1ebfu th\u1eddi gian g\u1ea7n t\u1edbi li\u1ec1u k\u1ebf ti\u1ebfp, th\u00ec h\u00e3y b\u1ecf qua li\u1ec1u b\u1ecb qu\u00ean v\u00e0 d\u00f9ng li\u1ec1u k\u1ebf ti\u1ebfp theo k\u1ebf ho\u1ea1ch b\u00ecnh th\u01b0\u1eddng. Kh\u00f4ng n\u00ean g\u1ea5p \u0111\u00f4i li\u1ec1u d\u00f9ng.<\/p>\n

      C\u1ea6N B\u1ea2O QU\u1ea2N THU\u1ed0C N\u00c0Y NH\u01af TH\u1ebe N\u00c0O<\/strong><\/h3>\n

      \u1ede nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30o<\/sup>C, n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

      NH\u1eeeNG D\u1ea4U HI\u1ec6U V\u00c0 TRI\u1ec6U CH\u1ee8NG KHI D\u00d9NG THU\u1ed0C QU\u00c1 LI\u1ec0U<\/strong><\/h3>\n

      Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u acetaminophen:<\/em><\/p>\n

      Bu\u1ed3n n\u00f4n, n\u00f4n, v\u00e0 \u0111au b\u1ee5ng th\u01b0\u1eddng x\u1ea3y ra trong v\u00f2ng 2-3 gi\u1edd sau khi u\u1ed1ng li\u1ec1u \u0111\u1ed9c c\u1ee7a thu\u1ed1c. Methemoglobin m\u00e1u, d\u1eabn \u0111\u1ebfn ch\u1ee9ng xanh t\u00edm da, ni\u00eam m\u1ea1c v\u00e0 m\u00f3ng tay l\u00e0 m\u1ed9t d\u1ea5u hi\u1ec7u \u0111\u1eb7c tr\u01b0ng nhi\u1ec5m \u0111\u1ed9c c\u1ea5p t\u00ednh d\u1eabn ch\u1ea5t p-aminophenol; m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf sulfhemoglobin c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1ea3n sinh. Tr\u1ebb em c\u00f3 khuynh h\u01b0\u1edbng t\u1ea1o methemoglobin d\u1ec5 h\u01a1n ng\u01b0\u1eddi l\u1edbn sau khi u\u1ed1ng acetaminophen.<\/p>\n

      Khi b\u1ecb ng\u1ed9 \u0111\u1ed9c n\u1eb7ng, ban \u0111\u1ea7u c\u00f3 th\u1ec3 c\u00f3 k\u00edch th\u00edch h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, k\u00edch \u0111\u1ed9ng, v\u00e0 m\u00ea s\u1ea3ng. Ti\u1ebfp theo c\u00f3 th\u1ec3 l\u00e0 \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: s\u1eefng s\u1edd, h\u1ea1 th\u00e2n nhi\u1ec7t, m\u1ec7t l\u1ea3, th\u1edf nhanh, n\u00f4ng; m\u1ea1ch nhanh, y\u1ebfu, kh\u00f4ng \u0111\u1ec1u, huy\u1ebft \u00e1p th\u1ea5p v\u00e0 suy tu\u1ea7n ho\u00e0n. Tr\u1ee5y m\u1ea1ch do gi\u1ea3m oxy huy\u1ebft t\u01b0\u01a1ng \u0111\u1ed1i v\u00e0 do t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf trung t\u00e2m, t\u00e1c d\u1ee5ng n\u00e0y ch\u1ec9 x\u1ea3y ra v\u1edbi li\u1ec1u r\u1ea5t l\u1edbn. S\u1ed1c c\u00f3 th\u1ec3 x\u1ea3y ra n\u1ebfu gi\u00e3n m\u1ea1ch nhi\u1ec1u. C\u01a1n co gi\u1eadt ngh\u1eb9t th\u1edf g\u00e2y t\u1eed vong c\u00f3 th\u1ec3 x\u1ea3y ra. Th\u01b0\u1eddng h\u00f4n m\u00ea x\u1ea3y ra tr\u01b0\u1edbc khi ch\u1ebft \u0111\u1ed9t ng\u1ed9t ho\u1eb7c sau v\u00e0i ng\u00e0y h\u00f4n m\u00ea.<\/p>\n

      D\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng th\u01b0\u01a1ng t\u1ed5n gan tr\u1edf n\u00ean r\u00f5 r\u1ec7t trong v\u00f2ng 2 \u0111\u1ebfn 4 ng\u00e0y sau khi u\u1ed1ng li\u1ec1u \u0111\u1ed9c. Aminotransferase huy\u1ebft t\u01b0\u01a1ng t\u0103ng (\u0111\u00f4i khi t\u0103ng r\u1ea5t cao) v\u00e0 n\u1ed3ng \u0111\u1ed9 bilirubin trong huy\u1ebft t\u01b0\u01a1ng c\u0169ng c\u00f3 th\u1ec3 t\u0103ng; th\u00eam n\u1eefa, khi th\u01b0\u01a1ng t\u1ed5n gan lan r\u1ed9ng, th\u1eddi gian prothrombin s\u1ebd k\u00e9o d\u00e0i. C\u00f3 th\u1ec3 10% ng\u01b0\u1eddi b\u1ec7nh b\u1ecb ng\u1ed9 \u0111\u1ed9c kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u0111\u1eb7c hi\u1ec7u \u0111\u00e3 c\u00f3 th\u01b0\u01a1ng t\u1ed5n gan nghi\u00eam tr\u1ecdng; trong s\u1ed1 \u0111\u00f3 10% \u0111\u1ebfn 20% cu\u1ed1i c\u00f9ng ch\u1ebft v\u00ec suy gan. Suy th\u1eadn c\u1ea5p c\u0169ng x\u1ea3y ra \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ec7nh. Sinh thi\u1ebft gan ph\u00e1t hi\u1ec7n ho\u1ea1i t\u1eed trung t\u00e2m ti\u1ec3u th\u00f9y tr\u1eeb v\u00f9ng quanh t\u0129nh m\u1ea1ch c\u1eeda. \u1ede nh\u1eefng tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng t\u1eed vong, th\u01b0\u01a1ng t\u1ed5n gan ph\u1ee5c h\u1ed3i sau nhi\u1ec1u tu\u1ea7n ho\u1eb7c nhi\u1ec1u th\u00e1ng.<\/p>\n

      Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u cafein:<\/em><\/p>\n

      \u0110au d\u1ea1 d\u00e0y \u2013 ru\u1ed9t, hoang t\u01b0\u1edfng nh\u1eb9, m\u1ea5t ng\u1ee7, ti\u1ec3u nhi\u1ec1u, m\u1ea5t n\u01b0\u1edbc, s\u1ed1t. C\u00e1c tri\u1ec7u ch\u1ee9ng nghi\u00eam tr\u1ecdng h\u01a1n c\u1ee7a qu\u00e1 li\u1ec1u cafein bao g\u1ed3m lo\u1ea1n nh\u1ecbp tim, co gi\u1eadt \u0111\u1ed9ng kinh co c\u1ee9ng.<\/p>\n

      C\u1ea6N PH\u1ea2I L\u00c0M G\u00cc KHI D\u00d9NG THU\u1ed0C QU\u00c1 LI\u1ec0U KHUY\u1ebeN C\u00c1O<\/strong><\/h3>\n

      Th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u1ef9 ho\u1eb7c \u0111\u1ebfn b\u1ec7nh vi\u1ec7n g\u1ea7n nh\u1ea5t.<\/p>\n

      Nh\u1edb mang theo nh\u00e3n thu\u1ed1c ho\u1eb7c l\u01b0\u1ee3ng thu\u1ed1c c\u00f2n l\u1ea1i \u0111\u1ec3 b\u00e1c s\u1ef9 bi\u1ebft thu\u1ed1c m\u00e0 b\u1ea1n \u0111\u00e3 d\u00f9ng.<\/p>\n

      NH\u1eeeNG \u0110I\u1ec0U C\u1ea6N TH\u1eacN TR\u1eccNG KHI D\u00d9NG THU\u1ed0C N\u00c0Y:<\/strong><\/h3>\n

      – <\/strong>Th\u1eadn tr\u1ecdng v\u00e0 c\u1ea3nh b\u00e1o \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ee9a ho\u1ea1t ch\u1ea5t <\/strong>a<\/strong>cetaminophen:<\/strong> B\u00e1c s\u0129 c\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a ph\u1ea3n \u1ee9ng tr\u00ean da nghi\u00eam tr\u1ecdng, c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u1eed vong bao g\u1ed3m h\u1ed9i ch\u1ee9ng Steven-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c (TEN), h\u1ed9i ch\u1ee9ng Lyell, h\u1ed9i ch\u1ee9ng ngo\u1ea1i ban m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p (AGEP).<\/p>\n

      – Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n ph\u1ea3i ng\u1eebng d\u00f9ng acetaminophen v\u00e0 \u0111i kh\u00e1m th\u1ea7y thu\u1ed1c ngay khi th\u1ea5y ph\u00e1t ban ho\u1eb7c c\u00e1c bi\u1ec3u hi\u1ec7n kh\u00e1c \u1edf da ho\u1eb7c c\u00e1c ph\u1ea3n \u1ee9ng m\u1eabn c\u1ea3m trong khi \u0111i\u1ec1u tr\u1ecb. Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed c\u00f3 c\u00e1c ph\u1ea3n \u1ee9ng nh\u01b0 v\u1eady kh\u00f4ng n\u00ean d\u00f9ng c\u00e1c ch\u1ebf ph\u1ea9m ch\u1ee9a acetaminophen.<\/p>\n

      – \u0110\u00f4i khi c\u00f3 nh\u1eefng ph\u1ea3n \u1ee9ng da g\u1ed3m ban d\u00e1t s\u1ea7n ng\u1ee9a v\u00e0 m\u00e0y \u0111ay; nh\u1eefng ph\u1ea3n \u1ee9ng m\u1eabn c\u1ea3m kh\u00e1c g\u1ed3m ph\u00f9 thanh qu\u1ea3n, ph\u00f9 m\u1ea1ch v\u00e0 nh\u1eefng ph\u1ea3n \u1ee9ng ki\u1ec3u ph\u1ea3n v\u1ec7 c\u00f3 th\u1ec3 \u00edt khi x\u1ea3y ra. Gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u v\u00e0 gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u \u0111\u00e3 x\u1ea3y ra v\u1edbi vi\u1ec7c s\u1eed d\u1ee5ng nh\u1eefng d\u1eabn ch\u1ea5t p-aminophenol, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng k\u00e9o d\u00e0i c\u00e1c li\u1ec1u l\u1edbn. Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 ban xu\u1ea5t huy\u1ebft gi\u1ea3m ti\u1ec3u c\u1ea7u \u0111\u00e3 x\u1ea3y ra khi d\u00f9ng acetaminophen. Hi\u1ebfm g\u1eb7p m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t \u1edf ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng acetaminophen.<\/p>\n

      – D\u00f9ng nhi\u1ec1u ch\u1ebf ph\u1ea9m ch\u1ee9a acetaminophen \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn h\u1eadu qu\u1ea3 c\u00f3 h\u1ea1i (nh\u01b0 qu\u00e1 li\u1ec1u acetaminophen).<\/p>\n

      – Ph\u1ea3i th\u1eadn tr\u1ecdng khi d\u00f9ng acetaminophen cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 thi\u1ebfu m\u00e1u t\u1eeb tr\u01b0\u1edbc, suy gan, suy th\u1eadn, ng\u01b0\u1eddi nghi\u1ec7n r\u01b0\u1ee3u, suy dinh d\u01b0\u1ee1ng m\u1ea1n t\u00ednh ho\u1eb7c b\u1ecb m\u1ea5t n\u01b0\u1edbc. Tr\u00e1nh d\u00f9ng li\u1ec1u cao, d\u00f9ng k\u00e9o d\u00e0i cho ng\u01b0\u1eddi b\u1ecb suy gan.<\/p>\n

      – U\u1ed1ng nhi\u1ec1u r\u01b0\u1ee3u c\u00f3 th\u1ec3 g\u00e2y t\u0103ng \u0111\u1ed9c t\u00ednh v\u1edbi gan c\u1ee7a acetaminophen, n\u00ean tr\u00e1nh ho\u1eb7c h\u1ea1n ch\u1ebf u\u1ed1ng r\u01b0\u1ee3u.<\/p>\n

      – Tr\u00e1nh u\u1ed1ng nhi\u1ec1u cafein (cafe, tr\u00e0) khi \u0111ang d\u00f9ng thu\u1ed1c.<\/p>\n

      – Thu\u1ed1c n\u00e0y c\u00f3 ch\u1ee9a:<\/em><\/p>\n

      Lactose. N\u1ebfu b\u1ea1n \u0111\u00e3 bi\u1ebft r\u1eb1ng b\u1ea1n kh\u00f4ng dung n\u1ea1p m\u1ed9t v\u00e0i lo\u1ea1i \u0111\u01b0\u1eddng th\u00ec h\u00e3y th\u00f4ng b\u00e1o cho b\u00e1c s\u1ef9 tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y.<\/p>\n

      Ponceau 4R lake, c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/p>\n

      – <\/em><\/strong>Th\u1eddi k\u1ef3 mang thai<\/strong>: Acetaminophen-cafein kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 mang thai do c\u00f3 th\u1ec3 gia t\u0103ng nguy c\u01a1 c\u00e2n n\u1eb7ng tr\u1ebb th\u1ea5p khi sinh v\u00e0 s\u1ea9y thai t\u1ef1 nhi\u00ean li\u00ean quan \u0111\u1ebfn cafein. V\u00ec v\u1eady, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho ph\u1ee5 n\u1eef c\u00f3 thai.<\/p>\n

      – Th\u1eddi k\u1ef3 cho con b\u00fa<\/strong>:<\/em> Cafein trong s\u1eefa m\u1eb9 c\u00f3 kh\u1ea3 n\u0103ng c\u00f3 t\u00e1c d\u1ee5ng k\u00edch th\u00edch tr\u1ebb s\u01a1 sinh b\u00fa m\u1eb9. V\u00ec v\u1eady, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n

      – \u1ea2nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi c\u00f4ng vi\u1ec7c: <\/strong>V\u00ec ch\u00f3ng m\u1eb7t c\u00f3 th\u1ec3 x\u1ea3y ra n\u00ean ph\u1ea3i th\u1eadn tr\u1ecdng trong c\u00e1c ho\u1ea1t \u0111\u1ed9ng nh\u01b0 l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, l\u00e0m vi\u1ec7c tr\u00ean cao v\u00e0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00e1c.<\/p>\n

      KHI N\u00c0O C\u1ea6N THAM V\u1ea4N B\u00c1C S\u1ef8, D\u01af\u1ee2C S\u1ef8<\/strong><\/h3>\n

      Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u ho\u1eb7c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/p>\n

      Khi \u0111ang d\u00f9ng thu\u1ed1c kh\u00e1c ho\u1eb7c m\u1ed9t lo\u1ea1i th\u1ef1c ph\u1ea9m.<\/p>\n

      N\u1ebfu c\u1ea7n th\u00eam th\u00f4ng tin xin h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u1ef9 <\/strong>ho\u1eb7c<\/strong> d\u01b0\u1ee3c s\u1ef9<\/strong>.<\/p>\n

      H\u1ea0N D\u00d9NG C\u1ee6A THU\u1ed0C:<\/strong> 36 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t. Kh\u00f4ng d\u00f9ng thu\u1ed1c khi qu\u00e1 h\u1ea1n d\u00f9ng.<\/h3>\n

      PH\u1ea6N II. H\u01af\u1edaNG D\u1eaaN S\u1eec D\u1ee4NG THU\u1ed0C CHO C\u00c1N B\u1ed8 Y T\u1ebe<\/strong><\/h2>\n

      D\u01af\u1ee2C L\u1ef0C H\u1eccC<\/strong>:<\/strong><\/h3>\n

      Nh\u00f3m d\u01b0\u1ee3c l\u00fd<\/em>: <\/em>Gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t.<\/p>\n

      M<\/em>\u00e3 ATC<\/em>: <\/em>N02BE51.<\/p>\n

      Acetaminophen<\/em><\/strong> l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a phenacetin.<\/p>\n

      Gi\u1ea3m \u0111au: C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au c\u1ee7a acetaminophen ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u0111\u1ea7y \u0111\u1ee7. Acetaminophen t\u00e1c \u0111\u1ed9ng ch\u1ee7 y\u1ebfu b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin \u1edf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 th\u1ea5p h\u01a1n b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t sinh xung \u0111\u1ed9ng g\u00e2y \u0111au th\u00f4ng qua t\u00e1c \u0111\u1ed9ng ngo\u1ea1i vi. T\u00e1c \u0111\u1ed9ng ngo\u1ea1i vi c\u0169ng c\u00f3 th\u1ec3 do \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin hay \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p ho\u1eb7c \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c ch\u1ea5t g\u00e2y nh\u1ea1y c\u1ea3m \u1edf c\u00e1c th\u1ee5 th\u1ec3 \u0111au do k\u00edch th\u00edch c\u01a1 h\u1ecdc ho\u1eb7c h\u00f3a h\u1ecdc.<\/p>\n

      H\u1ea1 s\u1ed1t: Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf trung khu \u0111i\u1ec1u nhi\u1ec7t v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i.\u00a0 Acetaminophen l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au \u2013 h\u1ea1 s\u1ed1t c\u00f3 th\u1ec3 thay th\u1ebf aspirin, tuy v\u1eady acetaminophen kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb vi\u00eam. V\u1edbi li\u1ec1u ngang nhau, acetaminophen c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au h\u1ea1 s\u1ed1t t\u01b0\u01a1ng t\u1ef1 nh\u01b0 aspirin. Acetaminophen l\u00e0m gi\u1ea3m th\u00e2n nhi\u1ec7t \u1edf ng\u01b0\u1eddi b\u1ec7nh s\u1ed1t nh\u01b0ng hi\u1ebfm khi l\u00e0m gi\u1ea3m th\u00e2n nhi\u1ec7t \u1edf ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. Acetaminophen, v\u1edbi li\u1ec1u \u0111i\u1ec1u tr\u1ecb, \u00edt t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn h\u1ec7 tim m\u1ea1ch v\u00e0 h\u00f4 h\u1ea5p, kh\u00f4ng l\u00e0m thay \u0111\u1ed5i c\u00e2n b\u1eb1ng acid \u2013 base, kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng, x\u01b0\u1edbc ho\u1eb7c ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y nh\u01b0 khi d\u00f9ng salicylat. Khi d\u00f9ng qu\u00e1 li\u1ec1u acetaminophen, ch\u1ea5t chuy\u1ec3n ho\u00e1 N-acetyl-p-benzoquinonimin g\u00e2y \u0111\u1ed9c n\u1eb7ng cho gan.<\/p>\n

      Cafein<\/em><\/strong> l\u00e0 m\u1ed9t d\u1eabn xu\u1ea5t xanthin \u0111\u01b0\u1ee3c chi\u1ebft t\u1eeb c\u00e0 ph\u00ea, ca cao hay \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p t\u1eeb acid uric. Cafein c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au c\u1ee7a acetaminophen.<\/p>\n

      D\u01af\u1ee2C \u0110\u1ed8NG H\u1eccC<\/strong><\/h3>\n

      Acetaminophen<\/em><\/strong> \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 h\u1ea7u nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Th\u1ee9c \u0103n gi\u00e0u carbon hydrat l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 h\u1ea5p thu c\u1ee7a acetaminophen. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t trong v\u00f2ng 30 \u0111\u1ebfn 60 ph\u00fat sau khi u\u1ed1ng v\u1edbi li\u1ec1u \u0111i\u1ec1u tr\u1ecb. Acetaminophen ph\u00e2n b\u1ed1 nhanh v\u00e0 \u0111\u1ed3ng \u0111\u1ec1u trong ph\u1ea7n l\u1edbn c\u00e1c m\u00f4 c\u1ee7a c\u01a1 th\u1ec3. Kho\u1ea3ng 25% acetaminophen trong m\u00e1u k\u1ebft h\u1ee3p v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a acetaminophen l\u00e0 1,25 – 3 gi\u1edd, c\u00f3 th\u1ec3 k\u00e9o d\u00e0i v\u1edbi li\u1ec1u g\u00e2y \u0111\u1ed9c ho\u1eb7c \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u01b0\u01a1ng t\u1ed5n gan. Sau li\u1ec1u \u0111i\u1ec1u tr\u1ecb, c\u00f3 th\u1ec3 t\u00ecm th\u1ea5y 90 \u0111\u1ebfn 100% thu\u1ed1c trong n\u01b0\u1edbc ti\u1ec3u trong ng\u00e0y th\u1ee9 nh\u1ea5t, ch\u1ee7 y\u1ebfu sau khi li\u00ean h\u1ee3p trong gan v\u1edbi acid glucuronic (kho\u1ea3ng 60%), acid sulfuric (kho\u1ea3ng 35%) ho\u1eb7c cystein (kho\u1ea3ng 3%); c\u0169ng ph\u00e1t hi\u1ec7n th\u1ea5y m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf nh\u1eefng ch\u1ea5t chuy\u1ec3n h\u00f3a hydroxyl – h\u00f3a v\u00e0 kh\u1eed acetyl. Tr\u1ebb nh\u1ecf \u00edt kh\u1ea3 n\u0103ng glucuro li\u00ean h\u1ee3p v\u1edbi thu\u1ed1c h\u01a1n so v\u1edbi ng\u01b0\u1eddi l\u1edbn. Acetaminophen b\u1ecb N-hydroxyl h\u00f3a b\u1edfi cytochrom P450<\/sub> \u0111\u1ec3 t\u1ea1o n\u00ean N-acetyl-benzoquinonimin (NAPQ), m\u1ed9t ch\u1ea5t trung gian c\u00f3 t\u00ednh ph\u1ea3n \u1ee9ng cao. Ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y b\u00ecnh th\u01b0\u1eddng ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c nh\u00f3m sulfhydryl trong glutathion v\u00e0 b\u1ecb kh\u1eed ho\u1ea1t t\u00ednh. Tuy nhi\u00ean, n\u1ebfu u\u1ed1ng li\u1ec1u cao acetaminophen, ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh v\u1edbi l\u01b0\u1ee3ng \u0111\u1ee7 \u0111\u1ec3 l\u00e0m c\u1ea1n ki\u1ec7t glutathion c\u1ee7a gan; trong t\u00ecnh tr\u1ea1ng \u0111\u00f3, ch\u1ea5t NAPQ kh\u00f4ng \u0111\u01b0\u1ee3c li\u00ean h\u1ee3p v\u1edbi glutathion g\u00e2y \u0111\u1ed9c cho t\u1ebf b\u00e0o gan, d\u1eabn \u0111\u1ebfn vi\u00eam v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ho\u1ea1i t\u1eed gan.<\/p>\n

      Cafein<\/em><\/strong> \u0111\u01b0\u1ee3c h\u1ea5p thu d\u1ec5 d\u00e0ng sau khi u\u1ed1ng v\u00e0 \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp c\u01a1 th\u1ec3. Cafein d\u1ec5 d\u00e0ng qua th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 n\u01b0\u1edbc b\u1ecdt; n\u1ed3ng \u0111\u1ed9 th\u1ea5p trong s\u1eefa m\u1eb9. Cafein qua nhau thai. \u1ede ng\u01b0\u1eddi l\u1edbn, cafein \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n \u1edf gan qua qu\u00e1 tr\u00ecnh oxy h\u00f3a, demethyl h\u00f3a, acetyl h\u00f3a, v\u00e0 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft trong n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng acid 1-methyluric, 1-methylxanthin, 7-methylxanthin, 1,7-dimethylxanthin (paraxanthin), 5-acetylamino-6-formylamino-3-methyluracil (AFMU), v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00e1c, ch\u1ec9 c\u00f3 kho\u1ea3ng 1% d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Cafein \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan nh\u1edd isoenzym cytochrom P450<\/sub> CYP1A2. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 3 \u2013 7 gi\u1edd \u1edf ng\u01b0\u1eddi l\u1edbn nh\u01b0ng kho\u1ea3ng 3 \u2013 4 ng\u00e0y \u1edf tr\u1ebb s\u01a1 sinh.<\/p>\n

      CH\u1ec8 \u0110\u1ecaNH<\/strong><\/h3>\n

      Gi\u1ea3m \u0111au nh\u1eb9 trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p<\/h4>\n

      – Nh\u1ee9c \u0111\u1ea7u, nh\u1ee9c r\u0103ng, \u0111au c\u01a1, vi\u00eam xoang.<\/p>\n

      – \u0110au nh\u1ee9c do th\u1ea5p kh\u1edbp.<\/p>\n

      – \u0110au b\u1ee5ng kinh.<\/p>\n

      – C\u1ea3m l\u1ea1nh th\u00f4ng th\u01b0\u1eddng.<\/p>\n

      H\u1ea1 s\u1ed1t.<\/p>\n

      C\u00c1CH D\u00d9NG<\/strong>, <\/strong>LI\u1ec0U D\u00d9NG<\/strong><\/h3>\n

      C\u00e1ch d\u00f9ng:<\/em><\/strong> Thu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n

      Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n

      Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i: U\u1ed1ng 1 – 2 vi\u00ean m\u1ed7i 6 gi\u1edd khi c\u00e1c tri\u1ec7u ch\u1ee9ng k\u00e9o d\u00e0i. Kh\u00f4ng d\u00f9ng qu\u00e1 8 vi\u00ean \/ 24 gi\u1edd ho\u1eb7c theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/p>\n

      CH\u1ed0NG CH\u1ec8 \u0110\u1ecaNH<\/strong><\/h3>\n

      – Ng\u01b0\u1eddi b\u1ec7nh qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n

      – B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n

      – Ng\u01b0\u1eddi b\u1ec7nh thi\u1ebfu h\u1ee5t glucose-6-phosphat dehydrogenase.<\/p>\n

      – Tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i.<\/p>\n

      L\u01afU \u00dd V\u00c0 TH\u1eacN TR\u1eccNG<\/strong><\/h3>\n

      – <\/strong>Th\u1eadn tr\u1ecdng v\u00e0 c\u1ea3nh b\u00e1o \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ee9a ho\u1ea1t ch\u1ea5t <\/strong>a<\/strong>cetaminophen:<\/strong> B\u00e1c s\u0129 c\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a ph\u1ea3n \u1ee9ng tr\u00ean da nghi\u00eam tr\u1ecdng, c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u1eed vong bao g\u1ed3m h\u1ed9i ch\u1ee9ng Steven-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c (TEN), h\u1ed9i ch\u1ee9ng Lyell, h\u1ed9i ch\u1ee9ng ngo\u1ea1i ban m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p (AGEP).<\/p>\n

      – Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n ph\u1ea3i ng\u1eebng d\u00f9ng acetaminophen v\u00e0 \u0111i kh\u00e1m th\u1ea7y thu\u1ed1c ngay khi th\u1ea5y ph\u00e1t ban ho\u1eb7c c\u00e1c bi\u1ec3u hi\u1ec7n kh\u00e1c \u1edf da ho\u1eb7c c\u00e1c ph\u1ea3n \u1ee9ng m\u1eabn c\u1ea3m trong khi \u0111i\u1ec1u tr\u1ecb. Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed c\u00f3 c\u00e1c ph\u1ea3n \u1ee9ng nh\u01b0 v\u1eady kh\u00f4ng n\u00ean d\u00f9ng c\u00e1c ch\u1ebf ph\u1ea9m ch\u1ee9a acetaminophen.<\/p>\n

      – \u0110\u00f4i khi c\u00f3 nh\u1eefng ph\u1ea3n \u1ee9ng da g\u1ed3m ban d\u00e1t s\u1ea7n ng\u1ee9a v\u00e0 m\u00e0y \u0111ay; nh\u1eefng ph\u1ea3n \u1ee9ng m\u1eabn c\u1ea3m kh\u00e1c g\u1ed3m ph\u00f9 thanh qu\u1ea3n, ph\u00f9 m\u1ea1ch v\u00e0 nh\u1eefng ph\u1ea3n \u1ee9ng ki\u1ec3u ph\u1ea3n v\u1ec7 c\u00f3 th\u1ec3 \u00edt khi x\u1ea3y ra. Gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u v\u00e0 gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u \u0111\u00e3 x\u1ea3y ra v\u1edbi vi\u1ec7c s\u1eed d\u1ee5ng nh\u1eefng d\u1eabn ch\u1ea5t p-aminophenol, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng k\u00e9o d\u00e0i c\u00e1c li\u1ec1u l\u1edbn. Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 ban xu\u1ea5t huy\u1ebft gi\u1ea3m ti\u1ec3u c\u1ea7u \u0111\u00e3 x\u1ea3y ra khi d\u00f9ng acetaminophen. Hi\u1ebfm g\u1eb7p m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t \u1edf ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng acetaminophen.<\/p>\n

      – D\u00f9ng nhi\u1ec1u ch\u1ebf ph\u1ea9m ch\u1ee9a acetaminophen \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn h\u1eadu qu\u1ea3 c\u00f3 h\u1ea1i (nh\u01b0 qu\u00e1 li\u1ec1u acetaminophen).<\/p>\n

      – Ph\u1ea3i th\u1eadn tr\u1ecdng khi d\u00f9ng acetaminophen cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 thi\u1ebfu m\u00e1u t\u1eeb tr\u01b0\u1edbc, suy gan, suy th\u1eadn, ng\u01b0\u1eddi nghi\u1ec7n r\u01b0\u1ee3u, suy dinh d\u01b0\u1ee1ng m\u1ea1n t\u00ednh ho\u1eb7c b\u1ecb m\u1ea5t n\u01b0\u1edbc. Tr\u00e1nh d\u00f9ng li\u1ec1u cao, d\u00f9ng k\u00e9o d\u00e0i cho ng\u01b0\u1eddi b\u1ecb suy gan.<\/p>\n

      – U\u1ed1ng nhi\u1ec1u r\u01b0\u1ee3u c\u00f3 th\u1ec3 g\u00e2y t\u0103ng \u0111\u1ed9c t\u00ednh v\u1edbi gan c\u1ee7a acetaminophen, n\u00ean tr\u00e1nh ho\u1eb7c h\u1ea1n ch\u1ebf u\u1ed1ng r\u01b0\u1ee3u.<\/p>\n

      – Tr\u00e1nh u\u1ed1ng nhi\u1ec1u cafein (cafe, tr\u00e0) khi \u0111ang d\u00f9ng thu\u1ed1c.<\/p>\n

      – Thu\u1ed1c n\u00e0y c\u00f3 ch\u1ee9a: <\/em><\/p>\n

      Lactose. B\u1ec7nh nh\u00e2n c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 di truy\u1ec1n hi\u1ebfm g\u1eb7p kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu h\u1ee5t lactose Lapp ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c n\u00e0y.<\/p>\n

      Ponceau 4R lake, c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/p>\n

      – <\/em><\/strong>Th\u1eddi k\u1ef3 mang thai<\/strong>: Acetaminophen-cafein kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 mang thai do c\u00f3 th\u1ec3 gia t\u0103ng nguy c\u01a1 c\u00e2n n\u1eb7ng tr\u1ebb th\u1ea5p khi sinh v\u00e0 s\u1ea9y thai t\u1ef1 nhi\u00ean li\u00ean quan \u0111\u1ebfn cafein. V\u00ec v\u1eady, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho ph\u1ee5 n\u1eef c\u00f3 thai.<\/p>\n

      – Th\u1eddi k\u1ef3 cho con b\u00fa<\/strong>:<\/em> Cafein trong s\u1eefa m\u1eb9 c\u00f3 kh\u1ea3 n\u0103ng c\u00f3 t\u00e1c d\u1ee5ng k\u00edch th\u00edch tr\u1ebb s\u01a1 sinh b\u00fa m\u1eb9. V\u00ec v\u1eady, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n

      – \u1ea2nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi c\u00f4ng vi\u1ec7c: <\/strong>V\u00ec ch\u00f3ng m\u1eb7t c\u00f3 th\u1ec3 x\u1ea3y ra n\u00ean ph\u1ea3i th\u1eadn tr\u1ecdng trong c\u00e1c ho\u1ea1t \u0111\u1ed9ng nh\u01b0 l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, l\u00e0m vi\u1ec7c tr\u00ean cao v\u00e0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00e1c.<\/p>\n

      T\u01af\u01a0NG T\u00c1C THU\u1ed0C<\/strong><\/h3>\n

      – T\u1ed1c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a acetaminophen c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u0103ng l\u00ean b\u1edfi metoclopramid ho\u1eb7c domperidon v\u00e0 h\u1ea5p th\u1ee5 gi\u1ea3m b\u1edfi colestyramin.<\/p>\n

      – U\u1ed1ng d\u00e0i ng\u00e0y li\u1ec1u cao acetaminophen l\u00e0m t\u0103ng nh\u1eb9 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng c\u1ee7a coumarin v\u00e0 d\u1eabn ch\u1ea5t indandion.<\/p>\n

      – C\u1ea7n ph\u1ea3i ch\u00fa \u00fd \u0111\u1ebfn kh\u1ea3 n\u0103ng g\u00e2y h\u1ea1 th\u00e2n nhi\u1ec7t nghi\u00eam tr\u1ecdng \u1edf ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng \u0111\u1ed3ng th\u1eddi phenothiazin v\u00e0 li\u1ec7u ph\u00e1p h\u1ea1 nhi\u1ec7t (nh\u01b0 acetaminophen).<\/p>\n

      – U\u1ed1ng qu\u00e1 nhi\u1ec1u r\u01b0\u1ee3u v\u00e0 d\u00e0i ng\u00e0y l\u00e0m t\u0103ng nguy c\u01a1 g\u00e2y \u0111\u1ed9c cho gan c\u1ee7a acetaminophen.<\/p>\n

      – C\u00e1c thu\u1ed1c ch\u1ed1ng co gi\u1eadt (g\u1ed3m phenytoin, barbiturat, carbamazepin), isoniazid, c\u00e1c thu\u1ed1c ch\u1ed1ng lao c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a acetaminophen tr\u00ean gan.<\/p>\n

      – Probenecid c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e0o th\u1ea3i acetaminophen v\u00e0 l\u00e0m t\u0103ng th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a acetaminophen.<\/p>\n

      – Cafein c\u00f3 kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP1A2 (nh\u01b0 clozapin) ho\u1eb7c v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng ho\u1eb7c \u1ee9c ch\u1ebf isoenzym n\u00e0y.<\/p>\n

      T\u00c1C D\u1ee4NG KH\u00d4NG MONG MU\u1ed0N<\/strong><\/h3>\n

      – Ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng nh\u01b0 h\u1ed9i ch\u1ee9ng Steven-Johnson, h\u1ed9i ch\u1ee9ng Lyell, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, m\u1ee5n m\u1ee7 ban \u0111\u1ecf to\u00e0n th\u00e2n c\u1ea5p tuy hi\u1ebfm x\u1ea3y ra, nh\u01b0ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u1eed vong. N\u1ebfu th\u1ea5y xu\u1ea5t hi\u1ec7n ban ho\u1eb7c c\u00e1c bi\u1ec3u hi\u1ec7n kh\u00e1c v\u1ec1 da, ph\u1ea3i ng\u1eebng d\u00f9ng thu\u1ed1c v\u00e0 th\u0103m kh\u00e1m th\u1ea7y thu\u1ed1c.<\/p>\n

      – Ban da v\u00e0 nh\u1eefng ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng kh\u00e1c th\u1ec9nh tho\u1ea3ng x\u1ea3y ra. Th\u01b0\u1eddng l\u00e0 ban \u0111\u1ecf ho\u1eb7c m\u00e0y \u0111ay, nh\u01b0ng \u0111\u00f4i khi n\u1eb7ng h\u01a1n v\u00e0 c\u00f3 th\u1ec3 k\u00e8m theo s\u1ed1t do thu\u1ed1c v\u00e0 th\u01b0\u01a1ng t\u1ed5n ni\u00eam m\u1ea1c. N\u1ebfu th\u1ea5y s\u1ed1t, b\u1ecdng n\u01b0\u1edbc quanh c\u00e1c h\u1ed1c t\u1ef1 nhi\u00ean, n\u00ean ngh\u0129 \u0111\u1ebfn h\u1ed9i ch\u1ee9ng Steven-Johnson, ph\u1ea3i ng\u1eebng thu\u1ed1c ngay. Qu\u00e1 li\u1ec1u acetaminophen c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng gan n\u1eb7ng v\u00e0 \u0111\u00f4i khi ho\u1ea1i t\u1eed \u1ed1ng th\u1eadn c\u1ea5p. Ng\u01b0\u1eddi b\u1ec7nh m\u1eabn c\u1ea3m v\u1edbi salicylat hi\u1ebfm khi m\u1eabn c\u1ea3m v\u1edbi acetaminophen v\u00e0 nh\u1eefng thu\u1ed1c c\u00f3 li\u00ean quan. Trong m\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p ri\u00eang l\u1ebb, acetaminophen \u0111\u00e3 g\u00e2y gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u.<\/p>\n

      – Th\u1ea7n kinh trung \u01b0\u01a1ng: K\u00edch \u0111\u1ed9ng, ch\u00f3ng m\u1eb7t.<\/p>\n

      – \u00cdt g\u1eb7p<\/em>, 1\/1000 < ADR < 1\/100<\/p>\n

      Da: Ban<\/p>\n

      D\u1ea1 d\u00e0y \u2013 ru\u1ed9t: Bu\u1ed3n n\u00f4n, n\u00f4n.<\/p>\n

      Huy\u1ebft h\u1ecdc: Lo\u1ea1n t\u1ea1o m\u00e1u (gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u), thi\u1ebfu m\u00e1u.<\/p>\n

      Th\u1eadn: B\u1ec7nh th\u1eadn, \u0111\u1ed9c t\u00ednh th\u1eadn khi l\u1ea1m d\u1ee5ng d\u00e0i ng\u00e0y.<\/p>\n

      – Hi\u1ebfm g\u1eb7p<\/em>, ADR < 1\/1000<\/p>\n

      Da: H\u1ed9i ch\u1ee9ng Steven-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, h\u1ed9i ch\u1ee9ng Lyell, m\u1ee5n m\u1ee7 ngo\u1ea1i ban to\u00e0n th\u00e2n c\u1ea5p t\u00ednh.<\/p>\n

      Kh\u00e1c: Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn<\/p>\n

      QU\u00c1 LI\u1ec0U V\u00c0 X\u1eec TR\u00cd<\/strong><\/h3>\n

      Acetaminophen:<\/strong><\/p>\n

      Tri\u1ec7u ch\u1ee9ng:<\/em><\/p>\n

      Bu\u1ed3n n\u00f4n, n\u00f4n, v\u00e0 \u0111au b\u1ee5ng th\u01b0\u1eddng x\u1ea3y ra trong v\u00f2ng 2-3 gi\u1edd sau khi u\u1ed1ng li\u1ec1u \u0111\u1ed9c c\u1ee7a thu\u1ed1c. Methemoglobin m\u00e1u, d\u1eabn \u0111\u1ebfn ch\u1ee9ng xanh t\u00edm da, ni\u00eam m\u1ea1c v\u00e0 m\u00f3ng tay l\u00e0 m\u1ed9t d\u1ea5u hi\u1ec7u \u0111\u1eb7c tr\u01b0ng nhi\u1ec5m \u0111\u1ed9c c\u1ea5p t\u00ednh d\u1eabn ch\u1ea5t p-aminophenol; m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf sulfhemoglobin c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1ea3n sinh. Tr\u1ebb em c\u00f3 khuynh h\u01b0\u1edbng t\u1ea1o methemoglobin d\u1ec5 h\u01a1n ng\u01b0\u1eddi l\u1edbn sau khi u\u1ed1ng acetaminophen.<\/p>\n

      Khi b\u1ecb ng\u1ed9 \u0111\u1ed9c n\u1eb7ng, ban \u0111\u1ea7u c\u00f3 th\u1ec3 c\u00f3 k\u00edch th\u00edch h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, k\u00edch \u0111\u1ed9ng, v\u00e0 m\u00ea s\u1ea3ng. Ti\u1ebfp theo c\u00f3 th\u1ec3 l\u00e0 \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: s\u1eefng s\u1edd, h\u1ea1 th\u00e2n nhi\u1ec7t, m\u1ec7t l\u1ea3, th\u1edf nhanh, n\u00f4ng; m\u1ea1ch nhanh, y\u1ebfu, kh\u00f4ng \u0111\u1ec1u, huy\u1ebft \u00e1p th\u1ea5p v\u00e0 suy tu\u1ea7n ho\u00e0n. Tr\u1ee5y m\u1ea1ch do gi\u1ea3m oxy huy\u1ebft t\u01b0\u01a1ng \u0111\u1ed1i v\u00e0 do t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf trung t\u00e2m, t\u00e1c d\u1ee5ng n\u00e0y ch\u1ec9 x\u1ea3y ra v\u1edbi li\u1ec1u r\u1ea5t l\u1edbn. S\u1ed1c c\u00f3 th\u1ec3 x\u1ea3y ra n\u1ebfu gi\u00e3n m\u1ea1ch nhi\u1ec1u. C\u01a1n co gi\u1eadt ngh\u1eb9t th\u1edf g\u00e2y t\u1eed vong c\u00f3 th\u1ec3 x\u1ea3y ra. Th\u01b0\u1eddng h\u00f4n m\u00ea x\u1ea3y ra tr\u01b0\u1edbc khi ch\u1ebft \u0111\u1ed9t ng\u1ed9t ho\u1eb7c sau v\u00e0i ng\u00e0y h\u00f4n m\u00ea.<\/p>\n

      D\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng th\u01b0\u01a1ng t\u1ed5n gan tr\u1edf n\u00ean r\u00f5 r\u1ec7t trong v\u00f2ng 2 \u0111\u1ebfn 4 ng\u00e0y sau khi u\u1ed1ng li\u1ec1u \u0111\u1ed9c. Aminotransferase huy\u1ebft t\u01b0\u01a1ng t\u0103ng (\u0111\u00f4i khi t\u0103ng r\u1ea5t cao) v\u00e0 n\u1ed3ng \u0111\u1ed9 bilirubin trong huy\u1ebft t\u01b0\u01a1ng c\u0169ng c\u00f3 th\u1ec3 t\u0103ng; th\u00eam n\u1eefa, khi th\u01b0\u01a1ng t\u1ed5n gan lan r\u1ed9ng, th\u1eddi gian prothrombin s\u1ebd k\u00e9o d\u00e0i. C\u00f3 th\u1ec3 10% ng\u01b0\u1eddi b\u1ec7nh b\u1ecb ng\u1ed9 \u0111\u1ed9c kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u0111\u1eb7c hi\u1ec7u \u0111\u00e3 c\u00f3 th\u01b0\u01a1ng t\u1ed5n gan nghi\u00eam tr\u1ecdng; trong s\u1ed1 \u0111\u00f3 10% \u0111\u1ebfn 20% cu\u1ed1i c\u00f9ng ch\u1ebft v\u00ec suy gan. Suy th\u1eadn c\u1ea5p c\u0169ng x\u1ea3y ra \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ec7nh. Sinh thi\u1ebft gan ph\u00e1t hi\u1ec7n ho\u1ea1i t\u1eed trung t\u00e2m ti\u1ec3u th\u00f9y tr\u1eeb v\u00f9ng quanh t\u0129nh m\u1ea1ch c\u1eeda. \u1ede nh\u1eefng tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng t\u1eed vong, th\u01b0\u01a1ng t\u1ed5n gan ph\u1ee5c h\u1ed3i sau nhi\u1ec1u tu\u1ea7n ho\u1eb7c nhi\u1ec1u th\u00e1ng.<\/p>\n

      X\u1eed tr\u00ed:<\/em><\/p>\n

      Ch\u1ea9n \u0111o\u00e1n s\u1edbm r\u1ea5t quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u acetaminophen. Khi nhi\u1ec5m \u0111\u1ed9c n\u1eb7ng, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 t\u00edch c\u1ef1c. C\u1ea7n r\u1eeda d\u1ea1 d\u00e0y trong m\u1ecdi tr\u01b0\u1eddng h\u1ee3p, t\u1ed1t nh\u1ea5t trong v\u00f2ng 4 gi\u1edd sau khi u\u1ed1ng. Li\u1ec7u ph\u00e1p gi\u1ea3i \u0111\u1ed9c ch\u00ednh l\u00e0 d\u00f9ng nh\u1eefng h\u1ee3p ch\u1ea5t sulfhydryl, c\u00f3 l\u1ebd t\u00e1c \u0111\u1ed9ng m\u1ed9t ph\u1ea7n do b\u1ed5 sung d\u1ef1 tr\u1eef glutathion \u1edf gan. N-acetylcystein c\u00f3 t\u00e1c d\u1ee5ng khi u\u1ed1ng ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch. Ph\u1ea3i d\u00f9ng thu\u1ed1c gi\u1ea3i \u0111\u1ed9c ngay l\u1eadp t\u1ee9c, c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t n\u1ebfu ch\u01b0a \u0111\u1ebfn 36 gi\u1edd k\u1ec3 t\u1eeb khi u\u1ed1ng acetaminophen. \u0110i\u1ec1u tr\u1ecb v\u1edbi N-acetylcystein c\u00f3 hi\u1ec7u qu\u1ea3 h\u01a1n khi cho thu\u1ed1c trong th\u1eddi gian d\u01b0\u1edbi 10 gi\u1edd sau khi u\u1ed1ng acetaminophen. Khi cho u\u1ed1ng, h\u00f2a lo\u00e3ng dung d\u1ecbch N-acetylcystein v\u1edbi n\u01b0\u1edbc ho\u1eb7c \u0111\u1ed3 u\u1ed1ng kh\u00f4ng c\u00f3 r\u01b0\u1ee3u \u0111\u1ec3 \u0111\u1ea1t dung d\u1ecbch 5% v\u00e0 ph\u1ea3i u\u1ed1ng trong v\u00f2ng 1 gi\u1edd sau khi pha. Cho u\u1ed1ng N-acetylcystein v\u1edbi li\u1ec1u \u0111\u1ea7u ti\u00ean l\u00e0 140 mg\/kg, sau \u0111\u00f3 cho ti\u1ebfp 17 li\u1ec1u n\u1eefa, m\u1ed7i li\u1ec1u 70 mg\/kg c\u00e1ch nhau 4 gi\u1edd m\u1ed9t l\u1ea7n. Ch\u1ea5m d\u1ee9t \u0111i\u1ec1u tr\u1ecb n\u1ebfu x\u00e9t nghi\u1ec7m acetaminophen trong huy\u1ebft t\u01b0\u01a1ng cho th\u1ea5y nguy c\u01a1 \u0111\u1ed9c h\u1ea1i gan th\u1ea5p.<\/p>\n

      T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a N-acetylcystein g\u1ed3m ban da (g\u1ed3m c\u1ea3 m\u00e0y \u0111ay, kh\u00f4ng y\u00eau c\u1ea7u ph\u1ea3i ng\u1eebng thu\u1ed1c), bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y v\u00e0 ph\u1ea3n \u1ee9ng ki\u1ec3u ph\u1ea3n v\u1ec7.<\/p>\n

      N\u1ebfu kh\u00f4ng c\u00f3 N-acetylcystein, c\u00f3 th\u1ec3 d\u00f9ng methionin. Ngo\u00e0i ra c\u00f3 th\u1ec3 d\u00f9ng than ho\u1ea1t v\u00e0\/ho\u1eb7c thu\u1ed1c t\u1ea9y mu\u1ed1i do ch\u00fang c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m h\u1ea5p th\u1ee5 acetaminophen.<\/p>\n

      Cafein:<\/strong><\/p>\n

      Tri\u1ec7u ch\u1ee9ng: <\/em>\u0110au d\u1ea1 d\u00e0y \u2013 ru\u1ed9t, hoang t\u01b0\u1edfng nh\u1eb9, m\u1ea5t ng\u1ee7, ti\u1ec3u nhi\u1ec1u, m\u1ea5t n\u01b0\u1edbc, s\u1ed1t. C\u00e1c tri\u1ec7u ch\u1ee9ng nghi\u00eam tr\u1ecdng h\u01a1n c\u1ee7a qu\u00e1 li\u1ec1u cafein bao g\u1ed3m lo\u1ea1n nh\u1ecbp tim, co gi\u1eadt \u0111\u1ed9ng kinh co c\u1ee9ng.<\/p>\n

      X\u1eed tr\u00ed: <\/em>\u0110i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u cafein ch\u1ee7 y\u1ebfu l\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3. Trong qu\u00e1 li\u1ec1u cafein \u0111\u01b0\u1eddng u\u1ed1ng c\u1ea5p t\u00ednh, ph\u1ea3i l\u00e0m tr\u1ed1ng d\u1ea1 d\u00e0y ngay l\u1eadp t\u1ee9c b\u1eb1ng c\u00e1ch g\u00e2y n\u00f4n ho\u1eb7c r\u1eeda d\u1ea1 d\u00e0y; c\u00f3 th\u1ec3 u\u1ed1ng than ho\u1ea1t t\u00ednh; v\u00e0 bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 c\u1ea7n \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u. U\u1ed1ng thu\u1ed1c l\u00e0m d\u1ecbu nh\u01b0 gel nh\u00f4m hydroxyd c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m k\u00edch th\u00edch ti\u00eau h\u00f3a. \u0110i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh b\u1eb1ng ti\u00eam t\u0129nh m\u1ea1ch diazepam ho\u1eb7c barbiturat nh\u01b0 natri pentobarbital.<\/p>\n

      C\u00c1C D\u1ea4U HI\u1ec6U C\u1ea6N L\u01afU \u00dd V\u00c0 KHUY\u1ebeN C\u00c1O<\/strong><\/h3>\n

      \u00a0\u00a0\u00a0 Kh\u00f4ng d\u00f9ng qu\u00e1 li\u1ec1u ch\u1ec9 \u0111\u1ecbnh. <\/strong><\/p>\n

      T\u00caN, \u0110\u1ecaA CH\u1ec8, BI\u1ec2U T\u01af\u1ee2NG C\u1ee6A C\u01a0 S\u1ede S\u1ea2N XU\u1ea4T<\/strong><\/h3>\n

      WHO-GMP <\/strong><\/p>\n

      C\u00d4NG TY C\u1ed4 PH\u1ea6N D\u01af\u1ee2C PH\u1ea8M OPV<\/strong><\/p>\n

      S\u1ed1 27, \u0110\u01b0\u1eddng 3A, Khu C\u00f4ng Nghi\u1ec7p Bi\u00ean H\u00f2a II, Ph\u01b0\u1eddng An B\u00ecnh, Tp. Bi\u00ean H\u00f2a, T\u1ec9nh \u0110\u1ed3ng Nai.<\/p>\n

       <\/p>\n

      NG\u00c0Y XEM X\u00c9T S\u1eecA \u0110\u1ed4I, C\u1eacP NH\u1eacT L\u1ea0I N\u1ed8I DUNG H\u01af\u1edaNG D\u1eaaN S\u1eec D\u1ee4NG THU\u1ed0C:<\/strong><\/h3>\n","protected":false},"excerpt":{"rendered":"

      TYDOL\u00ae Plus \u0110\u1ec3\u00a0xa t\u1ea7m tay tr\u1ebb em \u0110\u1ecdc k\u1ef9 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi d\u00f9ng Th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u1ef9 ho\u1eb7c d\u01b0\u1ee3c s\u1ef9 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c. PH\u1ea6N I. H\u01af\u1edaNG D\u1eaaN S\u1eec D\u1ee4NG THU\u1ed0C CHO NG\u01af\u1edcI B\u1ec6NH TH\u00c0NH PH\u1ea6N, H\u00c0M L\u01af\u1ee2NG C\u1ee6A THU\u1ed0C: M\u1ed7i vi\u00ean…<\/p>\n","protected":false},"featured_media":821,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_cat":[39],"product_tag":[],"class_list":["post-1019","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-tydol-analgesics"],"_links":{"self":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product\/1019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/comments?post=1019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media\/821"}],"wp:attachment":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media?parent=1019"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_cat?post=1019"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_tag?post=1019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}