{"id":1013,"date":"2026-05-19T09:51:55","date_gmt":"2026-05-19T02:51:55","guid":{"rendered":"https:\/\/opv.vn\/?post_type=product&p=1013"},"modified":"2026-05-19T09:51:55","modified_gmt":"2026-05-19T02:51:55","slug":"tydol-80","status":"publish","type":"product","link":"https:\/\/opv.vn\/en\/tydol-80\/","title":{"rendered":"TYDOL 80"},"content":{"rendered":"

TH\u00c0NH PH\u1ea6N <\/strong>C\u00d4NG TH\u1ee8C<\/strong> THU\u1ed0C<\/strong>: <\/strong>M\u1ed7i g\u00f3i 1,5 g ch\u1ee9a:<\/p>\n

Th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t<\/strong>: <\/strong>Acetaminophen \u2026\u2026\u2026\u202680 mg<\/p>\n

Th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c: <\/strong>\u0110\u01b0\u1eddng tr\u1eafng, lactose d\u1eadp th\u1eb3ng, h\u01b0\u01a1ng tr\u00e1i c\u00e2y h\u1ed7n h\u1ee3p, aspartam, microcrystallin cellulose & natri carboxymethyl cellulose.<\/p>\n

D\u1ea0NG B\u00c0O CH\u1ebe: <\/strong><\/p>\n

Thu\u1ed1c b\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng.<\/p>\n

Thu\u1ed1c b\u1ed9t \u0111\u1ed3ng nh\u1ea5t, kh\u00f4ng b\u1ecb v\u00f3n c\u1ee5c, m\u00e0u tr\u1eafng hay tr\u1eafng ng\u00e0, h\u01b0\u01a1ng tr\u00e1i c\u00e2y h\u1ed7n h\u1ee3p, v\u1ecb ng\u1ecdt<\/p>\n

CH\u1ec8 \u0110\u1ecaNH: <\/strong><\/p>\n

H\u1ea1 s\u1ed1t.<\/p>\n

Gi\u1ea3m \u0111au t\u1eeb nh\u1eb9 \u0111\u1ebfn v\u1eeba do: c\u1ea3m l\u1ea1nh, c\u1ea3m c\u00fam, nh\u1ee9c \u0111\u1ea7u, \u0111au h\u1ecdng, m\u1ecdc r\u0103ng, ch\u00edch ng\u1eeba, c\u1eaft ami\u0111an.<\/p>\n

Thu\u1ed1c d\u00f9ng \u0111i\u1ec1u tr\u1ecb cho tr\u1ebb em c\u00e2n n\u1eb7ng t\u1eeb 6 \u2013 20 kg.<\/p>\n

C\u00c1CH D\u00d9NG, <\/strong>LI\u1ec0U D\u00d9NG<\/strong>:<\/strong><\/p>\n

C\u00e1ch d\u00f9ng:<\/strong><\/p>\n

D\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng. Khu\u1ea5y \u0111\u1ec1u b\u1ed9t thu\u1ed1c v\u00e0o m\u1ed9t l\u01b0\u1ee3ng n\u01b0\u1edbc th\u00edch h\u1ee3p v\u00e0 u\u1ed1ng ngay sau khi pha.<\/p>\n

N\u1ebfu tr\u1ebb s\u1ed1t tr\u00ean\u00a038,5\u00b0C,\u00a0h\u00e3y l\u00e0m nh\u1eefng b\u01b0\u1edbc sau \u0111\u00e2y \u0111\u1ec3 t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c d\u00f9ng thu\u1ed1c.<\/p>\n

– C\u1edfi b\u1ecf b\u1edbt qu\u1ea7n \u00e1o c\u1ee7a tr\u1ebb.<\/p>\n

– Cho tr\u1ebb u\u1ed1ng th\u00eam ch\u1ea5t l\u1ecfng.<\/p>\n

– Kh\u00f4ng \u0111\u1ec3 tr\u1ebb \u1edf n\u01a1i qu\u00e1 n\u00f3ng.<\/p>\n

– N\u1ebfu c\u1ea7n, t\u1eafm cho tr\u1ebb b\u1eb1ng n\u01b0\u1edbc \u1ea5m, c\u00f3 nhi\u1ec7t \u0111\u1ed9 th\u1ea5p h\u01a1n 2\u00b0C so v\u1edbi th\u00e2n nhi\u1ec7t c\u1ee7a tr\u1ebb.<\/p>\n

Li\u1ec1u d\u00f9ng:<\/strong><\/p>\n

D\u1ea1ng thu\u1ed1c n\u00e0y d\u00e0nh cho tr\u1ebb c\u00e2n n\u1eb7ng t\u1eeb 6 \u0111\u1ebfn 20 kg<\/strong>\u00a0(kho\u1ea3ng 1 \u0111\u1ebfn 7 tu\u1ed5i).<\/p>\n

LI\u1ec0U D\u00d9NG PH\u1ea2I \u0110\u01af\u1ee2C T\u00cdNH THEO C\u00c2N N\u1eb6NG C\u1ee6A TR\u1eba.<\/strong><\/p>\n

Tu\u1ed5i th\u00edch h\u1ee3p t\u01b0\u01a1ng \u1ee9ng v\u1edbi c\u00e2n n\u1eb7ng \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y b\u00ean d\u01b0\u1edbi ch\u1ec9 \u0111\u1ec3 tham kh\u1ea3o. \u0110\u1ec3 tr\u00e1nh nguy c\u01a1 qu\u00e1 li\u1ec1u, c\u1ea7n ki\u1ec3m tra v\u00e0 x\u00e1c nh\u1eadn c\u00e1c thu\u1ed1c d\u00f9ng k\u00e8m (bao g\u1ed3m c\u1ea3 thu\u1ed1c k\u00ea \u0111\u01a1n v\u00e0 kh\u00f4ng k\u00ea \u0111\u01a1n) kh\u00f4ng ch\u1ee9a acetaminophen (xem “C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng<\/strong>“).<\/p>\n

TYDOL 80 n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng \u1edf li\u1ec1u t\u1eeb 10 \u2013 15 mg\/kg\/li\u1ec1u, m\u1ed7i 4 \u0111\u1ebfn 6 gi\u1edd, \u0111\u1ebfn t\u1ed5ng li\u1ec1u t\u1ed1i \u0111a m\u1ed7i ng\u00e0y l\u00e0 60 mg\/kg\/ng\u00e0y. Li\u1ec1u t\u1ed1i \u0111a m\u1ed7i ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 3 g.<\/p>\n\n\n\n\n\n\n\n\n
C\u00e2n n\u1eb7ng (kg)<\/strong><\/td>\nTu\u1ed5i<\/strong>\u00a0th\u00edch h\u1ee3p* (n\u0103m)<\/strong><\/td>\nH\u00e0m l\u01b0\u1ee3ng acetaminophen\/li\u1ec1u (mg)<\/strong><\/td>\nS\u1ed1 g\u00f3i\/ li\u1ec1u d\u00f9ng<\/strong><\/td>\nKho\u1ea3ng c\u00e1ch t\u1ed1i thi\u1ec3u d\u00f9ng thu\u1ed1c (gi\u1edd)<\/strong><\/td>\nLi\u1ec1u d\u00f9ng t\u1ed1i \u0111a m\u1ed7i ng\u00e0y (g\u00f3i)<\/strong><\/td>\n<\/tr>\n
6 \u0111\u1ebfn < 8<\/td>\n1 \u0111\u1ebfn < 2<\/td>\n80<\/td>\n1<\/td>\n6<\/td>\n4 (320 mg)<\/td>\n<\/tr>\n
8 \u0111\u1ebfn < 11<\/td>\n2 \u0111\u1ebfn < 3<\/td>\n80<\/td>\n1<\/td>\n4<\/td>\n6 (480 mg)<\/td>\n<\/tr>\n
11 \u0111\u1ebfn < 16<\/td>\n3 \u0111\u1ebfn < 6<\/td>\n160<\/td>\n2<\/td>\n6<\/td>\n8 (640 mg)<\/td>\n<\/tr>\n
16 \u0111\u1ebfn < 20<\/td>\n6 \u0111\u1ebfn < 7<\/td>\n160<\/td>\n2<\/td>\n4<\/td>\n12 (960 mg)<\/td>\n<\/tr>\n
\u2265 20<\/td>\n\u2265 7<\/td>\nD\u00f9ng m\u1ed9t d\u1ea1ng thu\u1ed1c u\u1ed1ng thay th\u1ebf kh\u00e1c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* Kho\u1ea3ng tu\u1ed5i th\u00edch h\u1ee3p t\u01b0\u01a1ng \u1ee9ng v\u1edbi c\u00e2n n\u1eb7ng ch\u1ec9 \u0111\u1ec3 tham kh\u1ea3o.<\/p>\n

Suy th\u1eadn:<\/strong><\/p>\n

\u1ede b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng, kho\u1ea3ng c\u00e1ch t\u1ed1i thi\u1ec3u gi\u1eefa m\u1ed7i l\u1ea7n d\u00f9ng thu\u1ed1c n\u00ean \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh theo b\u1ea3ng sau:<\/p>\n\n\n\n\n\n\n
\u0110\u1ed9 thanh th\u1ea3i creatinine<\/strong><\/td>\nKho\u1ea3ng c\u00e1ch d\u00f9ng thu\u1ed1c<\/strong><\/td>\n<\/tr>\n
Cl \u2265 50 ml\/ph\u00fat<\/td>\n4 gi\u1edd<\/td>\n<\/tr>\n
Cl 10 \u2013 50 ml\/ph\u00fat<\/td>\n6 gi\u1edd<\/td>\n<\/tr>\n
Cl < 10 ml\/ph\u00fat<\/td>\n8 gi\u1edd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Suy gan:<\/strong><\/p>\n

\u1ede b\u1ec7nh nh\u00e2n b\u1ec7nh gan m\u1ea1n t\u00ednh ho\u1eb7c b\u1ec7nh gan c\u00f2n b\u00f9 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy t\u1ebf b\u00e0o gan, nghi\u1ec7n r\u01b0\u1ee3u m\u1ea1n t\u00ednh, suy dinh d\u01b0\u1ee1ng k\u00e9o d\u00e0i (k\u00e9m d\u1ef1 tr\u1eef glutathione \u1edf gan), v\u00e0 m\u1ea5t n\u01b0\u1edbc, li\u1ec1u d\u00f9ng kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 3 g\/ng\u00e0y.<\/p>\n

T\u1ea7n su\u1ea5t v\u00e0 th\u1eddi \u0111i\u1ec3m d\u00f9ng thu\u1ed1c:<\/strong><\/p>\n

\u1ede tr\u1ebb em, c\u1ea7n c\u00f3 kho\u1ea3ng c\u00e1ch \u0111\u1ec1u gi\u1eefa m\u1ed7i l\u1ea7n d\u00f9ng thu\u1ed1c, c\u1ea3 ban ng\u00e0y l\u1eabn ban \u0111\u00eam, n\u00ean l\u00e0 kho\u1ea3ng 6 gi\u1edd, ho\u1eb7c \u00edt nh\u1ea5t l\u00e0 4 gi\u1edd. T\u1ea7n su\u1ea5t s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y gi\u00fap tr\u00e1nh \u0111\u01b0\u1ee3c nh\u1eefng bi\u1ebfn \u0111\u1ed9ng v\u1ec1 m\u1ee9c \u0111\u1ed9 \u0111au ho\u1eb7c s\u1ed1t.<\/p>\n

Tr\u01b0\u1eddng h\u1ee3p c\u00f3 b\u1ec7nh th\u1eadn n\u1eb7ng (suy th\u1eadn n\u1eb7ng), xem “Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng, suy th\u1eadn<\/strong>“.<\/p>\n

CH\u1ed0NG CH\u1ec8 \u0110\u1ecaNH<\/strong>:<\/strong><\/p>\n

Thu\u1ed1c n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n

    \n
  • Bi\u1ebft c\u00f3 d\u1ecb \u1ee9ng v\u1edbi acetaminophen ho\u1eb7c v\u1edbi propacetamol hydrochloride (ti\u1ec1n ch\u1ea5t c\u1ee7a acetaminophen) ho\u1eb7c c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1c c\u1ee7a thu\u1ed1c.<\/li>\n
  • B\u1ec7nh gan n\u1eb7ng ho\u1eb7c b\u1ec7nh gan \u0111ang ti\u1ebfn tri\u1ec3n.<\/li>\n
  • Thi\u1ebfu h\u1ee5t men Glucose-6-Phosphate Dehydrogenase (G6PD).<\/li>\n<\/ul>\n

    C\u1ea2NH B\u00c1O V\u00c0 TH\u1eacN TR\u1eccNG KHI D\u00d9NG THU\u1ed0C<\/strong>:<\/strong><\/p>\n

    C\u1ea3nh b\u00e1o:<\/strong><\/p>\n

    Ph\u1ea3i b\u00e1o ngay cho b\u00e1c s\u0129 khi d\u00f9ng qu\u00e1 li\u1ec1u, ho\u1eb7c nh\u1ee1 cho u\u1ed1ng li\u1ec1u qu\u00e1 cao.<\/p>\n

    Thu\u1ed1c n\u00e0y ch\u1ee9a acetaminophen. C\u00e1c thu\u1ed1c kh\u00e1c c\u0169ng ch\u1ee9a ho\u1ea1t ch\u1ea5t n\u00e0y. Kh\u00f4ng d\u00f9ng ph\u1ed1i h\u1ee3p nh\u1eefng thu\u1ed1c nh\u01b0 v\u1eady \u0111\u1ec3 tr\u00e1nh v\u01b0\u1ee3t qu\u00e1 li\u1ec1u h\u00e0ng ng\u00e0y \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh (xem “Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng”).<\/strong><\/p>\n

    Li\u1ec1u acetaminophen cao h\u01a1n li\u1ec1u khuy\u1ebfn c\u00e1o g\u00e2y n\u00ean nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng gan r\u1ea5t nghi\u00eam tr\u1ecdng. C\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u1ec1 t\u1ed5n th\u01b0\u01a1ng gan th\u01b0\u1eddng \u0111\u01b0\u1ee3c ghi nh\u1eadn \u0111\u1ea7u ti\u00ean sau 1 \u0111\u1ebfn 2 ng\u00e0y qu\u00e1 li\u1ec1u acetaminophen. C\u00e1c tri\u1ec7u ch\u1ee9ng t\u1ed5n th\u01b0\u01a1ng gan t\u1ed1i \u0111a th\u01b0\u1eddng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y sau
    \n3 \u2013 4 ng\u00e0y. C\u1ea7n s\u1eed d\u1ee5ng thu\u1ed1c gi\u1ea3i \u0111\u1ed9c c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t (xem “Qu\u00e1 li\u1ec1u v\u00e0 c\u00e1ch x\u1eed tr\u00ed<\/strong>“).<\/p>\n

    D\u00f9ng th\u1eadn tr\u1ecdng acetaminophen trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n

    – Suy t\u1ebf b\u00e0o gan.<\/p>\n

    – Suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh l\u1ecdc creatinine \u2264 30 ml\/ph\u00fat).<\/p>\n

    – Ch\u00e1n \u0103n, ch\u1ee9ng \u0103n v\u00f4 \u0111\u1ed9 ho\u1eb7c suy m\u00f2n, suy dinh d\u01b0\u1ee1ng k\u00e9o d\u00e0i (t\u1ee9c k\u00e9m d\u1ef1 tr\u1eef glutathione \u1edf gan).<\/p>\n

    – M\u1ea5t n\u01b0\u1edbc, gi\u1ea3m th\u1ec3 t\u00edch m\u00e1u.<\/p>\n

    B\u00e1c s\u0129 c\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a ph\u1ea3n \u1ee9ng tr\u00ean da nghi\u00eam tr\u1ecdng nh\u01b0 h\u1ed9i ch\u1ee9ng Steven-Johnson (SJS), h\u1ed9i ch\u1ee9ng ho\u1ea1i t\u1eed da nhi\u1ec5m \u0111\u1ed9c (TEN) hay h\u1ed9i ch\u1ee9ng Lyell, h\u1ed9i ch\u1ee9ng ngo\u1ea1i ban m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p t\u00ednh (AGEP).<\/p>\n

    Th\u1eadn tr\u1ecdng khi d\u00f9ng:<\/strong><\/p>\n

    N\u1ebfu tri\u1ec7u ch\u1ee9ng \u0111au dai d\u1eb3ng qu\u00e1 5 ng\u00e0y, ho\u1eb7c c\u00f2n s\u1ed1t qu\u00e1 3 ng\u00e0y, ho\u1eb7c thu\u1ed1c ch\u01b0a \u0111\u1ee7 hi\u1ec7u qu\u1ea3, ho\u1eb7c th\u1ea5y xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00e1c, kh\u00f4ng ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb m\u00e0 kh\u00f4ng h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129.<\/p>\n

    Tr\u01b0\u1eddng h\u1ee3p c\u00f3 b\u1ec7nh gan n\u1eb7ng, ho\u1eb7c b\u1ec7nh th\u1eadn, ph\u1ea3i h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc khi d\u00f9ng acetaminophen.<\/p>\n

    Thu\u1ed1c n\u00e0y c\u00f3 ch\u1ee9a:<\/em><\/p>\n

    Lactose. B\u1ec7nh nh\u00e2n c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 di truy\u1ec1n hi\u1ebfm g\u1eb7p kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu h\u1ee5t lactase to\u00e0n ph\u1ea7n ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c n\u00e0y.<\/p>\n

    \u0110\u01b0\u1eddng tr\u1eafng. B\u1ec7nh nh\u00e2n c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 di truy\u1ec1n hi\u1ebfm g\u1eb7p kh\u00f4ng dung n\u1ea1p fructose, k\u00e9m h\u1ea5p thu glucose-galactose ho\u1eb7c thi\u1ebfu h\u1ee5t sucrase-isomaltase kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c n\u00e0y.<\/p>\n

    40 mg aspartam\/g\u00f3i. Aspartam l\u00e0 m\u1ed9t ngu\u1ed3n phenylalanine. N\u00f3 g\u00e2y h\u1ea1i n\u1ebfu b\u1ec7nh nh\u00e2n b\u1ecb phenylketon ni\u1ec7u (PKU), m\u1ed9t r\u1ed1i lo\u1ea1n di truy\u1ec1n hi\u1ebfm g\u1eb7p trong \u0111\u00f3 c\u01a1 th\u1ec3 b\u1ecb t\u00edch t\u1ee5 phenylalanine v\u00ec kh\u00f4ng th\u1ec3 lo\u1ea1i b\u1ecf n\u00f3 \u0111\u00fang c\u00e1ch.<\/p>\n

    S\u1eec D\u1ee4NG THU\u1ed0C CHO PH\u1ee4 N\u1eee C\u00d3 THAI V\u00c0 CHO CON B\u00da<\/strong>:<\/strong><\/p>\n

    Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n

    \u1ea2NH H\u01af\u1edeNG C\u1ee6A THU\u1ed0C L\u00caN KH\u1ea2 N\u0102NG L\u00c1I XE, V\u1eacN H\u00c0NH M\u00c1Y M\u00d3C<\/strong>:<\/strong><\/p>\n

    Kh\u00f4ng li\u00ean quan.<\/p>\n

    T\u01af\u01a0NG T\u00c1C, T\u01af\u01a0NG K\u1ef4 C\u1ee6A THU\u1ed0C<\/strong>:<\/strong><\/p>\n

    T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/strong><\/p>\n

    N\u1ebfu b\u00e1c s\u0129 ch\u1ec9 \u0111\u1ecbnh \u0111o n\u1ed3ng \u0111\u1ed9 acid uric ho\u1eb7c \u0111\u01b0\u1eddng huy\u1ebft, b\u1ea1n c\u1ea7n b\u00e1o b\u00e1c s\u0129 l\u00e0 con b\u1ea1n \u0111ang d\u00f9ng thu\u1ed1c n\u00e0y.<\/p>\n

    \u0110\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u00e1c thu\u1ed1c, b\u1ea1n lu\u00f4n ph\u1ea3i b\u00e1o cho b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129 bi\u1ebft c\u00e1c thu\u1ed1c kh\u00e1c b\u1ea1n \u0111ang d\u00f9ng.<\/p>\n

    \u1ea2nh h\u01b0\u1edfng c\u1ee7a TYDOL 80 l\u00ean c\u00e1c thu\u1ed1c kh\u00e1c<\/em><\/p>\n

      \n
    • TYDOL 80 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng x\u1ea3y ra c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n khi d\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c.<\/li>\n
    • Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u:\u00a0acetaminophen c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng.<\/li>\n<\/ul>\n

      \u1ea2nh h\u01b0\u1edfng c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c l\u00ean TYDOL 80<\/em><\/p>\n

        \n
      • S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi phenytoin c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a acetaminophen v\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh \u0111\u1ed1i v\u1edbi gan. Nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng phenytoin n\u00ean tr\u00e1nh d\u00f9ng acetaminophen li\u1ec1u l\u1edbn v\u00e0\/ho\u1eb7c k\u00e9o d\u00e0i. C\u1ea7n theo d\u00f5i b\u1ec7nh nh\u00e2n v\u1ec1 d\u1ea5u hi\u1ec7u \u0111\u1ed9c t\u00ednh \u0111\u1ed1i v\u1edbi gan.<\/li>\n
      • Probenecid\u00a0c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m g\u1ea7n 2 l\u1ea7n v\u1ec1 \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a acetaminophen b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ef1 li\u00ean h\u1ee3p c\u1ee7a n\u00f3 v\u1edbi acid glucuronic. N\u00ean xem x\u00e9t gi\u1ea3m li\u1ec1u acetaminophen khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi probenecid.<\/li>\n
      • Salicylamide c\u00f3\u00a0th\u1ec3 k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a acetaminophen.<\/li>\n
      • C\u00e1c ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng enzyme:\u00a0c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi acetaminophen v\u1edbi c\u00e1c ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng enzyme. Nh\u1eefng ch\u1ea5t n\u00e0y bao g\u1ed3m: barbiturate, isoniazid, carbamazepine, rifampicin v\u00e0 ethanol (xem “Qu\u00e1 li\u1ec1u v\u00e0 c\u00e1ch x\u1eed tr\u00ed<\/strong>“).<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5 thu\u1ed1c:<\/strong> Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n

        T\u00c1C D\u1ee4NG KH\u00d4NG MONG MU\u1ed0N C\u1ee6A THU\u1ed0C<\/strong>:<\/strong><\/p>\n

        C\u0169ng nh\u01b0 \u0111\u1ed1i v\u1edbi t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c, thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra, \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi, nh\u1eefng ph\u1ea3n \u1ee9ng \u1edf c\u00e1c m\u1ee9c \u0111\u1ed9 n\u1eb7ng ho\u1eb7c nh\u1eb9.<\/p>\n

        C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 d\u01b0\u1edbi \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong theo d\u00f5i h\u1eadu m\u00e3i nh\u01b0ng t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n (t\u1ea7n su\u1ea5t) ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft.<\/p>\n

        R\u1ed1i lo\u1ea1n m\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft: gi\u1ea3m l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m b\u1ea1ch c\u1ea7u.<\/p>\n

        R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a: ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng.<\/p>\n

        R\u1ed1i lo\u1ea1n gan m\u1eadt: t\u0103ng men gan.<\/p>\n

        R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch: ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, ph\u00f9 Quincke, qu\u00e1 m\u1eabn.<\/p>\n

        Th\u0103m kh\u00e1m c\u1eadn l\u00e2m s\u00e0ng: gi\u1ea3m ch\u1ec9 s\u1ed1 INR, t\u0103ng ch\u1ec9 s\u1ed1 INR.<\/p>\n

        R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da: m\u00e0y \u0111ay, ban \u0111\u1ecf, ph\u00e1t ban, h\u1ed9i ch\u1ee9ng ngo\u1ea1i ban m\u1ee5n m\u1ee7 to\u00e0n th\u00e2n c\u1ea5p t\u00ednh, h\u1ed9i ch\u1ee9ng ho\u1ea1i t\u1eed da nhi\u1ec5m \u0111\u1ed9c, h\u1ed9i ch\u1ee9ng Stevens-Johnson.<\/p>\n

        R\u1ed1i lo\u1ea1n m\u1ea1ch: h\u1ea1 huy\u1ebft \u00e1p (tri\u1ec7u ch\u1ee9ng c\u1ee7a qu\u00e1 m\u1eabn).<\/p>\n

        Th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129 nh\u1eefng ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n

        QU\u00c1 LI\u1ec0U V\u00c0 <\/strong>C\u00c1CH <\/strong>X\u1eec TR\u00cd<\/strong>:<\/strong><\/p>\n

        Th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u0129 khi b\u1ecb qu\u00e1 li\u1ec1u ho\u1eb7c nh\u1ee1 b\u1ecb ng\u1ed9 \u0111\u1ed9c.<\/p>\n

        D\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng<\/strong><\/p>\n

        C\u00f3 th\u1ec3 g\u1eb7p nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi b\u1ec7nh gan, \u1edf b\u1ec7nh nh\u00e2n suy dinh d\u01b0\u1ee1ng k\u00e9o d\u00e0i v\u00e0 ng\u01b0\u1eddi d\u00f9ng thu\u1ed1c c\u1ea3m \u1ee9ng enzyme. \u0110\u1eb7c bi\u1ec7t qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y (Xem \u201cC\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c<\/strong>\u201d v\u00e0 \u201cT\u01b0\u01a1ng t\u00e1c, t\u01b0\u01a1ng k\u1ef5 c\u1ee7a thu\u1ed1c<\/strong>\u201d).<\/p>\n

        Nh\u1eefng tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n trong 24 gi\u1edd \u0111\u1ea7u, g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, ch\u00e1n \u0103n, da t\u00e1i, kh\u00f3 ch\u1ecbu v\u00e0 \u0111\u1ed5 m\u1ed3 h\u00f4i.<\/p>\n

        Qu\u00e1 li\u1ec1u khi d\u00f9ng m\u1ed9t li\u1ec1u cao h\u01a1n 7,5 g acetaminophen \u1edf ng\u01b0\u1eddi l\u1edbn, ho\u1eb7c 140 mg\/kg th\u1ec3 tr\u1ecdng \u1edf tr\u1ebb em s\u1ebd g\u00e2y vi\u00eam v\u00e0 h\u1ee7y t\u1ebf b\u00e0o gan, c\u00f3 th\u1ec3 g\u00e2y ho\u1ea1i t\u1eed ho\u00e0n to\u00e0n v\u00e0 kh\u00f4ng ph\u1ee5c h\u1ed3i, k\u00e9o theo suy t\u1ebf b\u00e0o gan, nhi\u1ec5m acid chuy\u1ec3n h\u00f3a, v\u00e0 b\u1ec7nh n\u00e3o c\u00f3 th\u1ec3 d\u1eabn t\u1edbi h\u00f4n m\u00ea v\u00e0 t\u1eed vong.<\/p>\n

        \u0110\u1ed3ng th\u1eddi, c\u00f3 t\u0103ng transaminase gan (AST, ALT), lactate dehydrogenase v\u00e0 bilirubin c\u00f9ng v\u1edbi gi\u1ea3m m\u1ee9c prothrombin c\u00f3 th\u1ec3 x\u1ea3y ra t\u1eeb 12 t\u1edbi 48 gi\u1edd sau khi d\u00f9ng thu\u1ed1c. C\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng c\u1ee7a t\u1ed5n th\u01b0\u01a1ng gan th\u01b0\u1eddng r\u00f5 r\u1ec7t l\u00fac ban \u0111\u1ea7u sau 1 – 2 ng\u00e0y, v\u00e0 \u0111\u1ea1t t\u1ed1i \u0111a sau 3 – 4 ng\u00e0y.<\/p>\n

        C<\/strong>\u00e1ch x\u1eed tr\u00ed<\/strong>:<\/strong><\/p>\n

        \u0110\u01b0a ngay \u0111\u1ebfn b\u1ec7nh vi\u1ec7n.<\/p>\n

        Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, ph\u1ea3i l\u1ea5y m\u1ed9t \u1ed1ng m\u00e1u c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t \u0111\u1ec3 \u0111\u1ecbnh l\u01b0\u1ee3ng n\u1ed3ng \u0111\u1ed9 acetaminophen trong huy\u1ebft t\u01b0\u01a1ng nh\u01b0ng kh\u00f4ng \u0111\u01b0\u1ee3c s\u1edbm h\u01a1n 4 gi\u1edd sau khi u\u1ed1ng acetaminophen.<\/p>\n

        Lo\u1ea1i b\u1ecf nhanh l\u01b0\u1ee3ng thu\u1ed1c \u0111\u00e3 d\u00f9ng b\u1eb1ng r\u1eeda d\u1ea1 d\u00e0y.<\/p>\n

        Li\u1ec7u ph\u00e1p gi\u1ea3i \u0111\u1ed9c ch\u00ednh l\u00e0 d\u00f9ng nh\u1eefng h\u1ee3p ch\u1ea5t sulfhydryl (v\u00ed d\u1ee5 nh\u01b0 N-acetylcysteine hay methionine), c\u00f3 l\u1ebd t\u00e1c \u0111\u1ed9ng m\u1ed9t ph\u1ea7n do b\u1ed5 sung d\u1ef1 tr\u1eef glutathione \u1edf gan. N-acetylcysteine c\u00f3 t\u00e1c d\u1ee5ng khi u\u1ed1ng ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch. Ph\u1ea3i d\u00f9ng thu\u1ed1c gi\u1ea3i \u0111\u1ed9c ngay l\u1eadp t\u1ee9c, c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t n\u1ebfu ch\u01b0a \u0111\u1ebfn 36 gi\u1edd k\u1ec3 t\u1eeb khi u\u1ed1ng acetaminophen. \u0110i\u1ec1u tr\u1ecb v\u1edbi N-acetylcysteine c\u00f3 hi\u1ec7u qu\u1ea3 h\u01a1n khi cho thu\u1ed1c trong th\u1eddi gian d\u01b0\u1edbi 10 gi\u1edd sau khi u\u1ed1ng acetaminophen. Khi cho u\u1ed1ng, h\u00f2a lo\u00e3ng dung d\u1ecbch N-acetylcysteine v\u1edbi n\u01b0\u1edbc ho\u1eb7c \u0111\u1ed3 u\u1ed1ng kh\u00f4ng c\u00f3 r\u01b0\u1ee3u \u0111\u1ec3 \u0111\u1ea1t dung d\u1ecbch 5% v\u00e0 ph\u1ea3i u\u1ed1ng trong v\u00f2ng 1 gi\u1edd sau khi pha. Cho u\u1ed1ng N-acetylcysteine v\u1edbi li\u1ec1u \u0111\u1ea7u ti\u00ean l\u00e0 140 mg\/kg, sau \u0111\u00f3 cho ti\u1ebfp 17 li\u1ec1u n\u1eefa, m\u1ed7i li\u1ec1u 70 mg\/kg c\u00e1ch nhau 4 gi\u1edd m\u1ed9t l\u1ea7n. Ch\u1ea5m d\u1ee9t \u0111i\u1ec1u tr\u1ecb n\u1ebfu x\u00e9t nghi\u1ec7m acetaminophen trong huy\u1ebft t\u01b0\u01a1ng cho th\u1ea5y nguy c\u01a1 \u0111\u1ed9c h\u1ea1i gan th\u1ea5p. C\u0169ng c\u00f3 th\u1ec3 d\u00f9ng N-acetylcysteine theo \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch: li\u1ec1u ban \u0111\u1ea7u l\u00e0 150 mg\/kg, pha trong 200 ml glucose 5%, ti\u00eam t\u0129nh m\u1ea1ch trong 15 ph\u00fat; sau \u0111\u00f3 truy\u1ec1n t\u0129nh m\u1ea1ch li\u1ec1u 50 mg\/kg trong 500 ml glucose 5% trong 4 gi\u1edd; ti\u1ebfp theo l\u00e0 100 mg\/kg trong 1 l\u00edt dung d\u1ecbch trong v\u00f2ng 16 gi\u1edd ti\u1ebfp theo. N\u1ebfu kh\u00f4ng c\u00f3 dung d\u1ecbch glucose 5% th\u00ec c\u00f3 th\u1ec3 d\u00f9ng dung d\u1ecbch natri clorid 0,9%. T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a N-acetylcysteine g\u1ed3m ban da (g\u1ed3m c\u1ea3 m\u00e0y \u0111ay, kh\u00f4ng y\u00eau c\u1ea7u ph\u1ea3i ng\u1eebng thu\u1ed1c), bu\u1ed3n n\u00f4n, n\u00f4n, \u1ec9a ch\u1ea3y, v\u00e0 ph\u1ea3n \u1ee9ng ki\u1ec3u ph\u1ea3n v\u1ec7. N\u1ebfu kh\u00f4ng c\u00f3 N-acetylcysteine, c\u00f3 th\u1ec3 d\u00f9ng methionine. N\u1ebfu \u0111\u00e3 d\u00f9ng than ho\u1ea1t tr\u01b0\u1edbc khi d\u00f9ng methionine th\u00ec ph\u1ea3i h\u00fat than ho\u1ea1t ra kh\u1ecfi d\u1ea1 d\u00e0y tr\u01b0\u1edbc. Ngo\u00e0i ra c\u00f3 th\u1ec3 d\u00f9ng than ho\u1ea1t v\u00e0\/ho\u1eb7c thu\u1ed1c t\u1ea9y mu\u1ed1i do ch\u00fang c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m h\u1ea5p th\u1ee5 acetaminophen.<\/p>\n

        \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng.<\/p>\n

        Ph\u1ea3i ti\u1ebfn h\u00e0nh l\u00e0m c\u00e1c x\u00e9t nghi\u1ec7m v\u1ec1 gan l\u00fac kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 nh\u1eafc l\u1ea1i m\u1ed7i 24 gi\u1edd. Trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p, transaminase gan tr\u1edf l\u1ea1i m\u1ee9c b\u00ecnh th\u01b0\u1eddng sau 1 – 2 tu\u1ea7n v\u1edbi s\u1ef1 ph\u1ee5c h\u1ed3i \u0111\u1ea7y \u0111\u1ee7 ch\u1ee9c n\u0103ng gan. Tuy nhi\u00ean, trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 n\u1eb7ng, c\u00f3 th\u1ec3 c\u1ea7n ph\u1ea3i gh\u00e9p gan.<\/p>\n

        D\u01af\u1ee2C L\u1ef0C H\u1eccC<\/strong>:<\/em><\/p>\n

        Nh\u00f3m d\u01b0\u1ee3c l\u00fd<\/em>: <\/em>Thu\u1ed1c gi\u1ea3m \u0111au v\u00e0 h\u1ea1 s\u1ed1t<\/p>\n

        M<\/em>\u00e3 ATC<\/em>: <\/em>N02BE01<\/p>\n

        Acetaminophen (paracetamol hay N-acetyl-p-aminophenol) l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a phenacetin, l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au \u2013 h\u1ea1 s\u1ed1t h\u1eefu hi\u1ec7u t\u01b0\u01a1ng t\u1ef1 aspirin. Tuy v\u1eady, kh\u00e1c v\u1edbi aspirin, acetaminophen kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb vi\u00eam. V\u1edbi li\u1ec1u ngang nhau, acetaminophen c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au v\u00e0 h\u1ea1 s\u1ed1t t\u01b0\u01a1ng t\u1ef1 aspirin.<\/p>\n

        Acetaminophen l\u00e0m gi\u1ea3m th\u00e2n nhi\u1ec7t \u1edf ng\u01b0\u1eddi b\u1ec7nh s\u1ed1t, nh\u01b0ng hi\u1ebfm khi l\u00e0m gi\u1ea3m th\u00e2n nhi\u1ec7t \u1edf ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. Thu\u1ed1c t\u00e1c \u0111\u1ed9ng l\u00ean v\u00f9ng d\u01b0\u1edbi \u0111\u1ed3i g\u00e2y h\u1ea1 nhi\u1ec7t, t\u1ecfa nhi\u1ec7t t\u0103ng do gi\u00e3n m\u1ea1ch v\u00e0 t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u ngo\u1ea1i bi\u00ean.<\/p>\n

        Acetaminophen th\u01b0\u1eddng \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0m thu\u1ed1c gi\u1ea3m \u0111au v\u00e0 h\u1ea1 s\u1ed1t, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 \u1edf ng\u01b0\u1eddi c\u00f3 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng salicylat ho\u1eb7c NSAID kh\u00e1c, nh\u01b0 ng\u01b0\u1eddi b\u1ecb hen, c\u00f3 ti\u1ec1n s\u1eed lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng v\u00e0 tr\u1ebb em.<\/p>\n

        D\u01af\u1ee2C \u0110\u1ed8NG H\u1eccC:<\/strong><\/p>\n

        H\u1ea5p thu:<\/em> Acetaminophen \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 h\u1ea7u nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Th\u1ee9c \u0103n gi\u00e0u carbohydrat l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 h\u1ea5p thu c\u1ee7a acetaminophen. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t trong v\u00f2ng 30 \u2013 60 ph\u00fat sau khi u\u1ed1ng v\u1edbi li\u1ec1u \u0111i\u1ec1u tr\u1ecb.<\/p>\n

        Ph\u00e2n b\u1ed1:<\/em> Acetaminophen ph\u00e2n b\u1ed1 nhanh v\u00e0 \u0111\u1ed3ng \u0111\u1ec1u trong ph\u1ea7n l\u1edbn c\u00e1c m\u00f4 c\u1ee7a c\u01a1 th\u1ec3. Kho\u1ea3ng 25% acetaminophen trong m\u00e1u k\u1ebft h\u1ee3p v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n

        Th\u1ea3i tr\u1eeb:<\/em> Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a acetaminophen l\u00e0 1,25 \u2013 3 gi\u1edd, c\u00f3 th\u1ec3 k\u00e9o d\u00e0i v\u1edbi li\u1ec1u g\u00e2y \u0111\u1ed9c ho\u1eb7c \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u01b0\u01a1ng t\u1ed5n gan. Sau li\u1ec1u \u0111i\u1ec1u tr\u1ecb, c\u00f3 th\u1ec3 t\u00ecm th\u1ea5y 90 \u2013 100% thu\u1ed1c trong n\u01b0\u1edbc ti\u1ec3u trong ng\u00e0y th\u1ee9 nh\u1ea5t, ch\u1ee7 y\u1ebfu sau khi li\u00ean h\u1ee3p trong gan v\u1edbi acid glucuronic (kho\u1ea3ng 60%), acid sulfuric (kho\u1ea3ng 35%) ho\u1eb7c cystein (kho\u1ea3ng 3%); c\u0169ng ph\u00e1t hi\u1ec7n th\u1ea5y m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf nh\u1eefng ch\u1ea5t chuy\u1ec3n h\u00f3a hydroxyl h\u00f3a v\u00e0 kh\u1eed acetyl. Tr\u1ebb nh\u1ecf \u00edt kh\u1ea3 n\u0103ng glucuro li\u00ean h\u1ee3p v\u1edbi thu\u1ed1c h\u01a1n so v\u1edbi ng\u01b0\u1eddi l\u1edbn.<\/p>\n

        Acetaminophen b\u1ecb N-hydroxyl h\u00f3a b\u1edfi cytochrom P450 \u0111\u1ec3 t\u1ea1o n\u00ean N-acetyl-benzoquinonimin (NAPQ), m\u1ed9t ch\u1ea5t trung gian c\u00f3 t\u00ednh ph\u1ea3n \u1ee9ng cao. Ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y b\u00ecnh th\u01b0\u1eddng ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c nh\u00f3m sulfhydryl trong glutathione v\u00e0 b\u1ecb kh\u1eed ho\u1ea1t t\u00ednh. Tuy nhi\u00ean, n\u1ebfu u\u1ed1ng li\u1ec1u cao acetaminophen, ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh v\u1edbi l\u01b0\u1ee3ng \u0111\u1ee7 \u0111\u1ec3 l\u00e0m c\u1ea1n ki\u1ec7t glutathione c\u1ee7a gan; trong t\u00ecnh tr\u1ea1ng \u0111\u00f3, ch\u1ea5t NAPQ kh\u00f4ng \u0111\u01b0\u1ee3c li\u00ean h\u1ee3p v\u1edbi glutathione g\u00e2y \u0111\u1ed9c cho t\u1ebf b\u00e0o gan, d\u1eabn \u0111\u1ebfn vi\u00eam v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ho\u1ea1i t\u1eed gan.<\/p>\n

        QUY C\u00c1CH \u0110\u00d3NG G\u00d3I:<\/strong><\/p>\n

        H\u1ed9p 12 g\u00f3i x 1,5 g thu\u1ed1c b\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng.<\/em><\/p>\n

        \u0110I\u1ec0U KI\u1ec6N B\u1ea2O QU\u1ea2N, H\u1ea0N D\u00d9NG, TI\u00caU CHU\u1ea8N CH\u1ea4T L\u01af\u1ee2NG C\u1ee6A THU\u1ed0C:<\/strong><\/p>\n

        B\u1ea3o qu\u1ea3n:<\/strong> \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 300<\/sup>C, n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

        H\u1ea1n d\u00f9ng: <\/strong>48 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t. Kh\u00f4ng d\u00f9ng thu\u1ed1c khi qu\u00e1 h\u1ea1n d\u00f9ng.<\/p>\n

        Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a thu\u1ed1c:<\/strong> TCCS<\/p>\n","protected":false},"excerpt":{"rendered":"

        TH\u00c0NH PH\u1ea6N C\u00d4NG TH\u1ee8C THU\u1ed0C: M\u1ed7i g\u00f3i 1,5 g ch\u1ee9a: Th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t: Acetaminophen \u2026\u2026\u2026\u202680 mg Th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c: \u0110\u01b0\u1eddng tr\u1eafng, lactose d\u1eadp th\u1eb3ng, h\u01b0\u01a1ng tr\u00e1i c\u00e2y h\u1ed7n h\u1ee3p, aspartam, microcrystallin cellulose & natri carboxymethyl cellulose. D\u1ea0NG B\u00c0O CH\u1ebe: Thu\u1ed1c b\u1ed9t pha h\u1ed7n d\u1ecbch u\u1ed1ng. Thu\u1ed1c b\u1ed9t \u0111\u1ed3ng nh\u1ea5t, kh\u00f4ng b\u1ecb v\u00f3n c\u1ee5c,…<\/p>\n","protected":false},"featured_media":806,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_cat":[39],"product_tag":[],"class_list":["post-1013","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-tydol-analgesics"],"_links":{"self":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product\/1013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/comments?post=1013"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media\/806"}],"wp:attachment":[{"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/media?parent=1013"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_cat?post=1013"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/opv.vn\/en\/wp-json\/wp\/v2\/product_tag?post=1013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}